Matrix metalloproteinases and their role in the development of remodeling in patients with acute myocardial infarction (review of literature)
The mechanisms of myocardial remodeling after myocardial infarction (MI) are of particular interest. Unfortunately, today science does not have an unambiguous answer to the question about the process of myocardial remodeling after MI. For example, in two clinically similar patients, without concomitant diseases, with the same localization of myocardial infarction, with a similar opening time of the coronary artery, in the long-term period, a completely different picture of heart failure develops, one has dilatation of the heart cavities, a decrease in the ejection fraction, and the other has absolutely no manifestations heart failure. Relatively recently, the fact of the influence of matrix metalloproteinases on the course of myocardial infarction was established; a sharp increase in their concentration in the acute and long-term period suggests speculation about their most important role in the processes of myocardial remodeling. In this review, we tried to summarize the existing data on the role of matrix metalloprotenases and MI, and tried to identify the existing pattern.
Bukatov V.V. 2020. Matrix metalloproteinases and their role in the development of remodeling in patients with acute myocardial infarction (review of literature). Challenges in Modern Medicine, 43 (3): 392–403 (in Russian). DOI: 10.18413/2687-0940-2020-43-3-392-403
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