The Effect of Glucocorticosteroids on the Osseointegration of Dental Implants: Pathogenetic Mechanisms and Clinical Consequences
Glucocorticosteroids (GCS) have a complex effect on bone metabolism, theoretically creating risks for dental implant osseointegration through glucocorticoid-induced osteoporosis (GIOP). Aim: to analyze the pathogenetic mechanisms of GCS effect on bone remodeling around dental implants and assess clinical consequences. Materials and methods: an analytical literature review was conducted in PubMed, Scopus, and eLibrary databases (2018–2025) using keywords: glucocorticoids, osseointegration, dental implants, osteoporosis. Results: pathogenetic mechanisms (suppressed osteogenesis, increased resorption, inhibited angiogenesis) create serious theoretical risks. However, clinical studies demonstrate that with careful treatment planning (two-stage protocol, adequate integration period) GCS intake does not preclude high success rates (up to 99 % osseointegration). Conclusions: long-term GCS therapy is not an absolute contraindication for dental implantation. Risk minimization strategies include bone metabolism assessment, pharmacological correction, osteoinductive implant surfaces, and careful monitoring.
Bayramzade F.Sh., Ivanov S.Yu., Muraev A.A. 2026. The Effect of Glucocorticosteroids on the Osseointegration of Dental Implants: Pathogenetic Mechanisms and Clinical Consequences. Challenges in Modern Medicine, 49(1): 77–85 (in Russian). DOI: 10.52575/2687-0940-2026-49-1-77-85. EDN: UXCTSP
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