Assessment of Vitamin D Availability Status and the State of Bone Mineral Density in Postmenopausal Women
The metabolism of bone tissue throughout life depends on the level of sex hormones. After menopause, there is a change in the nature of bone metabolism with a shift in its balance in the direction of bone resorption processes. Estrogen deficiency is a trigger factor in the pathogenesis of postmenopausal osteoporosis. Chronic vitamin D deficiency is also an important link in the pathogenesis of most forms of osteoporosis, as it plays an essential role in ensuring bone metabolism. The aim of the study was to assess the status of vitamin D supplementation and bone mineral density in postmenopausal women. A random sample was selected, consisting of 101 female patients, residents of the Pridnestrovian Moldavian Republic, with an average age of 62.7 ± 6.7 years. The study was conducted from January to December to determine the plasma concentration of 25-hydroxyvitamin D from venous blood samples. The state of bone mineral density was analyzed in all patients based on the results of two-energy X-ray absorptiometry. Vitamin D deficiency status was registered in 84.2 % of the surveyed postmenopausal women. It was found that low vitamin D availability in this age group is significantly associated with the risk of bone remodeling (p < 0.01).
Likrizon S.V., Golivets T.P. 2026. Assessment of Vitamin D Availability Status and the State of Bone Mineral Density in Postmenopausal Women. Challenges in Modern Medicine, 49(1): 5–15 (in Russian). DOI: 10.52575/2687-0940-2026-49-1-5-15. EDN: AZGZGI
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