Features of the humoral immune response to antigens of opportunistic microorganisms in patients with systemic lupus erythematosus
Currently, much attention is paid to the study of the role of opportunistic microorganisms in systemic lupus erythematosus, researchers are increasingly interested in various aspects of their potential influence. The mechanisms of interaction of opportunistic microorganisms with the patient's immune system, contributing to the development and maintenance of chronic inflammation and autoimmunity, require further comprehensive research. Objective: to study the features of the humoral immune response to antigens of opportunistic microorganisms in patients with SLE. Clinical and laboratory examination of 26 patients with SLE and 30 conditionally healthy individuals of the control group was carried out. The level of IgG antibodies to the antigens of opportunistic bacteria was studied in the blood serum of the examined individuals by the ELISA method. Analysis of the presence of class G antibodies to opportunistic bacteria in the blood serum of patients with systemic lupus erythematosus revealed a more frequent detection of antibodies to the antigens of bacteria of the genus Streptococcus, S. aureus, E. coli, K. rpeimopiae compared with the control group. SLE patients had a statistically significantly higher level of IgG antibodies to the antigens of S. aureus, S. epidermidis, E. coli, and K. pneumoniae. The change in the level of antibodies characterizes the features of the antigenic load and confirms the presence of dysbiotic disorders in systemic lupus erythematosus, which should be taken into account when implementing optimal therapy.
Gulneva M.Yu. 2021 Features of the humoral immune response to antigens of opportunistic microorganisms in patients with systemic lupus erythematosus. Challenges in Modern Medicine. 44 (3): 278–285 (in Russian). DOI: 10.52575/2687-0940-2021-44-3-278-285
While nobody left any comments to this publication.
You can be first.
Lila A.M., Galushko E.A., Gordeev A.V., Semashko A.S. 2021. Rol' mikrobioma v patogeneze Immune-vospalitel'nykh zabolevanii (diskussionnye voprosy) [The role of microbiome in the pathogenesis of immune-mediated inflammatory diseases: controversial issues]. Sovremennaya revmatologiya, 1: 15–19.
Shostak N.A., Klimenko A.A. 2011. Sistemnaya krasnaya volchanka v praktike vracha-internista: sovremennye voprosy diagnostiki i lecheniya [Systemic lupus erythematosus in the practice of an internist: modern issues of diagnosis and treatment]. Consil. Medicum, 9: 51–56.
Azzouz D., Omarbekova А., Adriana Heguy А., Schwudke D., Gisch N., Rovin В., Caricchio R., Buyon Р., Alekseyenko А., Silverman G. 2019. Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal, Ann Rheum Dis. 78 (7): 947–956.
Bagavant Н., Dunkleberger М., Wolska N., Sroka М., Rasmussen A., Adrianto I., Montgomery С., Sivils К., Guthridge J., James J., Merrill J., Deshmuk U. 2019. Antibodies to periodontogenic bacteria are associated with higher disease activity in lupus patients, Clin. Exp. Rheumatol., 37 (1): 106–111.
Battaglia М., Garrett-Sinha L. А. 2021. Bacterial infections in lupus: Roles in promoting immune activation and in pathogenesis of the disease. J. Transl. Autoimmun., 4: 100078.
Howe H.S., Leung B.P.L. 2019. Anti-cytokine autoantibodies in systemic lupus erythematosus. Cells, 9.
Huang C., Yi X., Long H., Zhang G., Wu H., Zhao M., Lu Q., Huang C. J. 2020. Disordered cutaneous microbiota in systemic lupus erythematosus. Autoimmun. 108: 102391.
Katz-Agranov N., Zandman-Goddard G. 2017. The microbiome and systemic lupus erythematosus. Immunol Res. 65 (2): 432–437.
Kiriakidou M., Ching C.L. 2020. Systemic Lupus Erythematosus. Ann. Intern. Med., 2; 172 (11): ITC81-ITC96.
Konig M.F. 2020. The microbiome in autoimmune rheumatic disease. Best Pract. Res. Clin. Rheumatol., 34 (1): 101473.
Lopez P., de Paz B., Rodriguez-Carrio J., Hevia A., Sanchez B., Margolles A. 2016. Th17 responses and natural IgM-antibodies are related to gut microbiota composition in systemic lupus erythematosus patients. Sci. Rep., 6: 24072.
Li H., Limenitakis J.P., Greiff V., Yilmaz B., Schären O., Urbaniak C., Zünd M., Lawson M., Young I.D., Rupp S., Heikenwälder M., McCoy K.D., Hapfelmeier S., Ganal-Vonarburg S.C., Macpherson A.J. 2020. Mucosal or systemic microbiota exposures shape the B cell repertoire. Nature. 584 (7820): 274–278.
Meesiri S. 2017. Pyomyositis in a patient with systemic lupus erythaematosus and a review of the literature. BMJ Case Rep. 18: 10.
Ostrov B.E., Amsterdam D. 2017. Immunomodulatory interplay of the microbiome and therapy of rheumatic diseases. Immunol. Invest. 46 (8): 769–792.
Pachucki R.J., Corradetti C., Kohler L., Ghadiali J., Gallo P.M., Nicastro L., Tursi S.A., Gallucci S., Tükel Ç., Caricchio R. 2020. Persistent Bacteriuria and Antibodies Recognizing Curli/eDNA Complexes from Escherichia coli are linked to Flares in Systemic Lupus Erythematosus Arthritis. Rheumatol. 72 (11): 1872–1881.
Qiu C.C., Caricchio R., Gallucci S. 2019. The Role of Bacterial Infections in the Extracellular Exposure of Lupus. Nuclear Autoantigens Front Immunol. 8; 10: 2608.
Visitación N., Robles-Vera I., Toral M. 2019. Protective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosus, Nutrients, 11 (11): 2676.
Yacoub R., Alexander J., Wlaschin J., McGregor M., Alexander J. 2018. Lupus: The microbiome angle. Immunobiology, 223 (6–7): 460–465.
Yu H., Nagafuchi Y., Fujio K. 2021. Clinical and Immunological Biomarkers for Systemic Lupus Erythematosus. Biomolecules, 22; 11 (7): 928.
Zhong D., Wu C., Zeng X., Wang Q. 2018. The role of gut microbiota in the pathogenesis of rheumatic diseases, Clin. Rheumatol., 37 (1): 25–34.