THE ROLE OF TRIGGER FACTORS AND PREDICTORS IN THE DEVELOPMENT OF CARDIOVASCULAR DISEASE IN THE ELDERLY (REVIEW OF LITERATURE)

M. А. Bazarova
N. I. Zhernakova
M. Yu. Skorkina

The main markers of aging are changes in the biochemical profile, in particular, the level of glucose and the concentration of lipids and lipoproteins in the blood. Hyperglycemia and dyslipidemia are the main factors in the development of cardiovascular diseases, and therefore, the study of lipid profile and glucose levels in the elderly is of particular relevance. The review objective is to assess the glycemic status and evaluate the lipid profile in modern populations of people. The review presents data on the gender and age characteristics of the distribution of cholesterol, analyzes the reference values of laboratory parameters of the lipid profile and level for a group of elderly patients. According to the analysis, it is difficult to interpret the results of laboratory tests in the elderly, since international standards are accepted for a small number of indicators. The determination and use of reference intervals of different age groups can be useful to enhance better clinical interpretation of biochemical values in geriatric population.

Keywords: dyslipidemia, glucose level, elderly patient, diabetes, cardiovascular diseases, age reference limits.

DOI: 10.18413/2687-0940-2020-43-1-54-64

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Bazarova M.А., Zhernakova N.I., Skorkina M.Yu. 2020. The role of trigger factors and predictors in the development of cardiovascular disease in the elderly (review of literature). Challenges in Modern Medicine, 43(1): 54–64 (in Russian). DOI

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Algoritmy specializirovannoj medicinskoj pomoshhi bol'nym saharnym diabetom. Klinicheskiye rekomendatii MZ RF [Standarts of specialized diabetes care]. 2019. Dedova I.I., Shestakovoj M.V., Majorova A.Ju., 17–19, 157.
Ahmetov A.S., Kurochkin I.O., Zubkov A.A. 2014. Saharnyj diabet i serdechno-sosudistye zabolevaniya. Rossijskij medicinskij zhurnal, 22 (13): 943–958.
Igonina N.A., Zhuravleva E.A., Kondrasheva E.A., Torshina I.G, Tchaschikhina E.V., Makarova T.A., Kopayeva L.B., Sysoyeva S.N. 2013. Analiz dannyh massovogo issledovanija urovnja holesterina u naselenija (k voprosu o referentnyh intervalakh) [The analysis of data of large study of cholesterol level in population: on the issue of reference values of cholesterol]. Klinicheskaja laboratornaja diagnostika, 1: 11–17.
Igonina N.A., Zhuravleva E.A., Kondrasheva E.A., Torshina I.G., Chashchikhina E.V., Makarova T.A., Kopaeva L.B., Sysoeva S.N. 2012. Uroven' holesterina v populjacii vzroslogo naselenija RF 20–70 let [The cholesterol level in Russian adults aged 20–70 years]. Ateroskleroz i dislipidemii, 4: 69–71.
Report of the WHO Council, 2007. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia. Available at: who.int/publications/list/9241594934/ru (accessed 19 January 2020).
Pronina E.A. 2013. Saharnyj diabet vtorogo tipa v geriatricheskoj praktike [Type 2 diabetes in geriatric practice]. Sibirskoe medicinskoe obozrenie, 6: 93.
Referentnye intervaly ili «norma» (ocenka rezul'tatov laboratornyh issledovanij) [Reference intervals or «norm» (evaluation of laboratory results]. Available at: nmtmed.ru/vracham/articles (accessed 21 December 2019).
Saprina T.V., Fajzulina N.M. 2016. Saharnyj diabet 2 tipa u lic pozhilogo vozrasta – reshennye i nereshyonnye voprosy [Diabetes type 2 diabetes in the elderly – solved and unsolved questions]. Saharnyj diabet, 19 (4): 322–330.
Samburova E.V., Siluyanova N.A., Slusar N.M. 2012. Analysis of oral glucose tolerance test in the diagnosis of diabetes mellitus and hyperglycemia in aged and senile patien. Kliniko-laboratornyj konsilium, 3 (43): 72–77.
Tereshina E.V., Pleteneva O.P., Osokina N. E., Aprosin Yu.D., Zakiev E.P. 2013. Dislipidemija v starshih vozrastnyh gruppah: gendernye razlichija [Dyslipidaemias in the elderly and the very old: gender differences]. Ateroskleroz, 9 (1): 14–19.
Urazgildeeva S.A., Nizhegorodcev M.Yu., Sadovnikov P.S., Olkhovik A.Yu., Nokhrin D.Yu., Muzalevskaya M.V., Shugurova I.V., Malenkovskaya D.G., Tregubov A.V., Gurevich V.S. 2017. Vozrastnye i gendernye osobennosti lipidnogo spektra krovi gorodskih zhitelej (po rezul'tatam kross-sekcionnogo issledovanija) [Age and Gender Peculiarities of Blood Lipids in Urban Residents (cross-sectional study results)]. Racional'naja farmakoterapija v kardiologii, 13 (5): 638–643.
Ushkalova E.A., Tkacheva O.N., Runikhina N.K., Chukhareva N.A., Bevz A.Yu. 2016. Effektivnost' i bezopasnost' gipolipidemicheskih preparatov v kachestve sredstv pervichnoj i vtorichnoj profilaktiki serdechno-sosudistyh zabolevanij u lic pozhilogo vozrasta [Efficacy and safety of lipid-lowering drugs in primary and secondary prevention of cardiovascular diseases in the elderly]. Racional'naja farmakoterapija v kardiologii, 12 (3): 351–357.
Adeli K., Higgins V., Nieuwesteeg M., Raizman J.E., Chen Y., Wong S.L., Blais D. 2015. Biochemical marker reference values across pediatric, adult, and geriatric ages: establishment of robust pediatric and adult reference intervals on the basis of the canadian health measures survey. Clinical Chemistry, 61 (8): 1049–1062.
Bartke A 2008. Impact of reduced insulin-like growth factor-1/insulin signaling on aging in mammals: novel findings. Aging Cell, 7 (3): 285–290.
Chia C.V., Egan J.W., Ferrucci L. 2018. Age-related changes in glucose metabolism, hyperglycemia, and cardiovascular risk. Circulation Research, 123: 886–904.
Cowie C.C., Rust K.F., Ford E.S. 2009. Full accounting of diabetes and pre-diabetes in the U.S. population in 1988–1994 and 2005–2006. Diabetes Care, 32: 287–294.
Eapen D.J., Kalra G.L., Rifai L., Eapen C.A., Merchant N., Khan B.V. 2010. Raising HDL cholesterol in women. Int. J. Womens Health, 1: 181–191.
European guidelines on cardiovascular disease prevention in clinical practice. European Heart Journal. 2003. 24: 1601–1610.
European guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. European Heart Journal 2019. 00: 22-23, 37.
Fink R.I., Kolterman O.G., Griffin J., Olefsky J.M. 1983. Mechanisms of insulin resistance in aging. J. Clin. Invest. 71: 1523–1535.
Granfone A., Campos H., McNamara J.R., Schaefer M. M., Lamon-Fava S., Ordovas J.M., Schaefer E.J. 1992. Effects of estrogen replacement on plasma lipoproteins and apolipoproteins in postmenopausal, dyslipidemic women. Metubolism, 41: 1193–1198.
Grundy S.M., Cleeman J.I., Merz N.B., Brewer H.B., Clark L.T., Hunninghake D.B. 2004. Implication of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. Circulation, 110: 227–239.
Gumbiner B., Thorburn A.W., Ditzler T.M. 1992. Role of impaired intracellular glucose metabolism in the insulin resistance of aging. Metanolism. 41: 1115–11121.
Iversen A., Jensen J.S., Scharling H., Schnohr P. 2009. Hypercholesterolemia and risk of coronary heart disease in the elderly: impact of age: the Copenhagen City Heart Study. Eur. J. Intern. Med. 20 (2): 139–144.
Marhoum T.A., Abdrabo A.A., Lutfi M.F. 2013. Effects of age and gender on serum lipid profile in over 55 years-old-apparently healthy Sudanes individuals. Asian J. of Biomedical and Pharmacological Science, 3 (19): 10–14.
Mc Auley M.T., Wilkinson D.J., Jones J.J., Kirkwood T.B. 012. A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation. BMC Syst. Biol., 6: 130.
Mekonnen Z., Amuamuta A., Mulu W., Yimer M., Zenebe Y., Adem Y., Abera B., Gebeyehu W., Gebregziabher Y. 2017. Clinical chemistry reference intervals of healthy adult populations in Gojjam Zones of Amhara National Regional State, Northwest Ethiopia. PLoS ONE 12:9 (e0184665).
Medrano M.J., Pastor R., Boix R., Del Barrio J.L., Damia´n J., A´ lvarez R. 2007. Riesgo coronario atribuible a los factores de riesgo cardiovascular en poblacio´n espanola. Rev Esp Cardiol, 60: 1250–1260.
Meneilly G.S., Ryan A.S., Veldhuris J.D., Elahi D. 1997. Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretory in older individuals. J. Clin. Endoctinol. Metab. 82: 40-88-4093.
Murakata Y., Fujimaki T., Yamada Y. 2015. Age-related changes in clinical parameters and their associations with common complex diseases. Biomed. Rep. 3 (6): 767–777.
Natali A., Toshi E., Camastra S., Gastaldelli A., Groop L., Ferrannini E. 2000. Determibabts of postabsorbtive endogenous glucose output in bob-diabetic sunjects. European Group for the Study of Insulin Resistance (EGIR). Diabetologia. 43: 1266–1272.
Noordam R., Gunn D.A., Tomlin C.C., Maier A.B., Mooijaart S.P., de Craen A.J.M., van Heemst D. 2013. High serum glucose levels are associated with a higher perceived age. Age, 35: 189–195.
O’Meara N.M., Sturis J., Van Cauter E., Polonsky K.S., 1993. Lacj of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-dependent diabetes mellitus. J. Clin. Invest. 92: 262–271.
Paolisso G., Scheen A.J., Giugliano D., Sgamnato S., Albert A., Varricchio M., D’Onofrio F., Lefebvre P.J. 1991. Pilsatile insulin delivery has greater metanolic effects than continuous hormone administration in man: importance of pulse frequency. J. Clin. Endocrinol. Metab. 72: 607–615.
Polonsky K.S., Givaen B.D., Van Cauter E. 1988. Twenty-four-hour profiles and palatial patterns of insulin secretion in normal and obese subjects. J. Clin. Invest. 81: 442–448.
Sacco R.L., Benson R.T., Kargman D.E. 2001. High-density lipoprotein cholesterol and ischemic stroke in the elderly: the Northern Manhattan Stroke Study. JAMA, 285: 2729–2735.
Seshadri S., Beiser A., Kelly-Hayes M. 2006. The lifetime risk of stroke: estimates from the Framingham Study. Stroke, 37: 345–350.
Souza J.D., Rebiero A.Q., Wartinbo K.O., Franco F.S., Wartins M.V., Rodrigues W.G., Wick J.Y., Tinoco A.L.A. 2–15. Lipid profile and associated factors among elderly people, attended at the Family Heaalth Strategy, Vicosa MG. Nutricion Hospitalaria, 32 (2): 771–778.
Stumvoll M., Goldstein B.J., van Haeften T.W. 2005. Type 2 diabetes: Principles of pathogenesis and therapy. Lancet, 365: 1333–1346.
Sturis J., Scheen A.J., Leproult R., Polonsky K.S., van Cauter E. 24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations. J. Clin Invest. 95: 1464–1471.
Wallace R.B., Colsher P.L. 1992. Blood lipid distributions in older persons. Prevalence and correlates of hyperlipidemia. Ann Epidemiol, 2 (1–2): 15–21.
Wei M., Gibbons L.W., Mitchell T.L., Kampert J.B., Stern M.P., Blair S.N. 2000. Low fasting plasma glucose levels as a predictor of cardiovascular disease and all-cause mortality. Circulation, 101 (17): 2047–2052.
Westendorp R.G., van Heemst D., Rozing M.P., Frolich M., Mooijaart S.P., Blauw G.J., Beekman M., Heijmans B.T., de Craen A.J., Slagboom P.E. 2009. Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study. J. Am. Geriatr. Soc. 57 (9): 1634–1637.
Woodward M., Patel A., Zoungas S. Woodward M., Patel A., Zoungas S., Liu L., Pan C., Poulter N., Januszewicz A., Tandon N., Joshi P., Heller S., Neal B., Chalmers J. 2011. Does glycemic control offer similar benefits among patients with diabetes in different regions of the world? Results from the ADVANCE trial. Diabetes Care, 34 (12): 2491–2495.
Zhai P., Liu S., Zhong Z., Liu J. 2019. Age- and sex-related difference of lipid profile in patients with ischemic stroke in China. Medicine, 97: 23 (e10930).

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