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Acomys Cahirinus as a Promising Species for Studying Myocardial Regeneration in Comparison with Classical Models

Myocardial infarction remains the leading cause of mortality worldwide, resulting in irreversible cardiomyocyte loss and scar tissue formation. This review aims to analyze Acomys cahirinus as a promising model for studying myocardial regeneration. Materials and Methods: A systematic search for articles published over the past five years was conducted in PubMed, Google Scholar, and eLIBRARY databases using keywords in Russian and English, selected in accordance with the study objective. Results: In Acomys, a significant restoration of cardiac function was observed: ejection fraction increased from 25% to 65% within four weeks, accompanied by reduced infarct size (18% vs. 76% in Mus), decreased fibrosis, and active cardiomyocyte proliferation. Unique features of Acomys cahirinus include enhanced vascular density in scar tissue, a "youthful" cardiomyocyte phenotype (predominance of mononuclear diploid cells, expression of T-type calcium channels), and a suppressed inflammatory response dominated by M2 macrophages. Conclusion: Acomys cahirinus represents a groundbreaking model for investigating myocardial regeneration mechanisms, offering novel pathways for developing therapies aimed at stimulating cardiac repair in humans. These findings highlight the critical role of immune modulation and extracellular matrix remodeling in regenerative medicine.

DOI: 10.52575/2687-0940-2025-48-3-320-331
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