The Use of Cryosupernatant Plasma Fraction in the Complex Treatment for the Correction of Thrombohemorrhagic Syndrome in Septic Patients
Purulent-inflammatory diseases are widespread and account for 1/3 of all surgical pathology. A severe life-threatening condition is the development of sepsis, with a mortality rate of up to 43 %. The aim of the study was to compare the dynamics of the course of thrombohemorrhagic syndrome with the use of cryosupernatant plasma fraction and freshly frozen plasma in patients with phlegmon and sepsis. Two groups of patients with phlegmon of soft tissues and sepsis were formed. Cryosupernatant plasma fraction transfusions were performed in the main group (34 patients, 47.9 %) as part of cryoplasma–enzyme therapy, and in the comparison group (37 patients, 52.1 %) with freshly frozen plasma. A study of hemostasis parameters indicated the presence of tombohemorrhagic syndrome. The effectiveness of the therapy was evaluated 8–10 days after its start. The addition of complex therapy with cryosupernatant plasma fraction contributes to more effective relief of thrombohemorrhagic syndrome compared with the use of freshly frozen plasma and improved treatment results, which is manifested in accelerated wound cleansing and filling with granulation tissue for 3.7 days, a 1.7-fold reduction in mortality, and the absence of complications of the septic process of a thrombotic or thromboembolic nature.
Tseimakh E.A., Zinchenko V.Yu., Kalashnikov A.V., Lavrinenko O.Yu., Shalabod E.A. 2025. The Use of Cryosupernatant Plasma Fraction in the Complex Treatment for the Correction of Thrombohemorrhagic Syndrome in Septic Patients. Challenges in Modern Medicine, 48(2): 259–274 (in Russian). DOI: 10.52575/2687-0940-2025-48-2-259-274. EDN: WVFNVQ
While nobody left any comments to this publication.
You can be first.
Al-Kanani E.S., Kulikovsky V.F., Gostischev V.K., Yarosh A.L., Karpachev A.A., Soloshenko A.V., Zharko S.V., Linnik M.S. 2020. Treatment of Purulent Soft Tissue Infection: From History to the Present (Literary Review). Actual Problems of Medicine. 43(1): 155–164 (in Russian). doi: 10.18413/2687-0940-2020-43-1-155-164
Barantsevich E.R., Barinov A.N., Vorobyeva O.V., Kazyulin A.N., Strakhov M.A. 2020. Interdisciplinary Problem of Inflammation. Consilium Medicum. 22(9): 96–101 (in Russian). doi: 10.26442/20751753.2020.9.200453
Galstyan G.M., Gaponova T.V., Sherstnev F.S., Kupryashov A.A., Olovnikova N.I., Zozulya N.I., Troitskaya V.V., Mazurok V.A., Pevtsov D.E., Salimov E.L., Trakhtman P.E., Savchenko V.G. 2020. Clinical Use of Cryosupernatant Plasma. Hematology and Transfusiology. 65(3): 351–359 (in Russian). https://doi.org/10.35754/0234-5730-2020-65-3-351-359
Gomanova L.I., Brazhnikov A.Y. 2021. Sepsis in the XXI Century: Etiology, Risk Factors, Epidemiological Features, Complications, Prevention. Epidemiology and Vaccinal Prevention. 20(3): 107–117 (in Russian). https://doi.org/10.31631/2073-3046-2021-20-3-107-117
Gomanova L.I. 2020. “Septic Shock: Perspective Methods of Diagnostics and Therapy Based on Immunopathogenesis”. Medical Immunology (Russia). Meditsinskaya Immunologiya. 22(3): 459–472 (in Russian). doi: 10.15789/1563-0625-SSP-1862
Gusev E.Yu., Zotova N.V., Chereshnev V.A. 2021. Sepsis-3: New Edition – Old Problems. Analysis from the Perspective of General Pathology. Russian. Journal of Infection and Immunity. 11(4): 649–662 (in Russian). doi: 10.15789/2220-7619-SAN-1629.
Kulikov A.V., Shifman E.M., Protsenko D.N., Zabolotskikh I.B., Ovezov A.M., Roitman E.V., Artymuk N.V., Astakhov A.A., Belokrinitskaya T.E., Ronenson A.M., Gorokhovsky V.S., Matkovsky A.A., Raspopin Yu.S., Ryazanova O.V., Pylaeva N.Y. 2022. Diagnosis and Intensive Therapy of Disseminated Intravascular Coagulation Syndrome in Massive Blood Loss in Obstetrics (Guidelines). Russian Journal of Anesthesiology and Reanimatology. (2): 5–23 (in Russian). https://doi.org/10.17116/anaesthesiology20220215
Litvitsky P.F. 2020. Violations of Regional Blood Flow and Microcirculation. Regional Blood Circulation and Microcirculation. 19(1): 82–92 (in Russian).
Plotkin L.L. 2021. Refractory Septic Shock (Part 1). Messenger of Anesthesiology and Resuscitation. 18(2): 77–83 (in Russian). https://doi.org/10.21292/2078-5658-2021-18-2-77-83
Rudnov V.A., Kalabukhov V.V. 2016. Sepsis-3: Updated Key Provisions, Potential Problems and Further Practical Steps. Vestnik anesteziologii i reanimatsii. – Bulletin of Anesthesiology and Resuscitation. 13(4): 4–11 (in Russian). https://doi.org/10.21292/2078-5658-2016-13-4-4-11
Seliverstov E.I., Lobastov K.V., Ilyukhin E.A., Apkhanova T.V., Akhmetzyanov R.V., Akhtyamov I.F., Barinov V.E., Bakhmetyev A.S., Belov M.V., Bobrov S.A., Bozhkova S.A., Bredikhin R.A., Bulatov V.L., Vavilova T.V., Vardanyan A.V., Vorobyova N.A., Gavrilov E.K., Gavrilov S.G., Golovina V.I., Gorin A.S., Jenina O.V., Dianov S.V., Efremova O.I., Zhukovets V.V., Zamyatin M.N., Ignatiev I.A., Kalinin R.E., Kamaev A.A., Kaplunov O.A., Karimova G.N., Karpenko A.A., Kasimova A.R., Katelnitskaya O.V., Katelnitsky I.I., Katorkin S.E., Knyazev R.I., Konchugova T.V., Kopenkin S.S., Koshevoy A.P., Kravtsov P.F., Krylov A.Yu., Kulchitskaya D.B., Laberko L.A., Lebedev I.S., Malanin D.A., Matyushkin A.V., Mzhavanadze N.D., Moiseev S.V., Mushtin N.E., Nikolaeva M.G., Pelevin A.V., Petrikov A.S., Piradov M.A., Pikhanova J.M., Poddubnaya I.V., Porembskaya O.Ya., Potapov M.P., Pyregov A.V., Rachin A.P., Rogachevsky O.V., Ryabinkina Yu.V., Sapelkin S.V., Sonkin I.N., Soroka V.V., Sushkov S.A., Schastlivtsev I.V., Tikhilov R.M., Tryakin A.A., Fokin A.A., Khoronenko V.E., Khruslov M.V., Tsaturyan A.B., Ced A.N., Cherkashin M.A., Chechulova A.V., Chuiko S.G., Shimanko A.I., Shmakov R.G., Yavelov I.S., Yashkin M.N., Kiriyenko A.I., Zolotukhin I.A., Stoyko Yu.M., Suchkov I.A. 2023. Prevention, Diagnostics and Treatment of Deep Vein Thrombosis. Russian Experts Consensus. Journal of Venous Disorders. 17(3): 152–296 (in Russian). https://doi.org/10.17116/flebo202317031152
Stepanov E.A., Kurashvili L.V., Mikulyak N.I., Moiseev Ya.P., Kinzirsky A.S. 2021. Features of Microcirculation in Periodontal Disease in Various Systemic Diseases. Izvestiya vysshikh uchebnykh zavedeniy. The Volga Region. Medical Sciences. (2): 137–150 (in Russian). doi: 10.21685/2072-3032-2021-2-13
Trubchanina Yu.A., Zemskova V.A., Berezhnova T.A., Dyadina K.S., Luneva E.A., Zemskov A.M. 2024. Improving the Clinical and Laboratory Effectiveness of Basic Treatment of Purulent Soft Tissue Infection Due to a Complex of a Metabolite with Multivalent Systemic Immunotherapy. Nauka molodykh (Eruditio Juvenium). 12(2): 165–174 (in Russian). doi: 10.23888/HMJ2024122165-174
Tseimakh E.A., Zinchenko V.Yu., Lavrinenko O.Yu., Chernenko V.V., Kalashnikov A.V., Tseimakh M.E., Shalabod E.A. 2021. Elimination of Microcirculatory Disorders in the Complex Treatment of Patients with Sepsis. Bulletin of Medical Science. 2(22): 78–88 (in Russian). doi.org/10.31684/25418475_2021_2_78
Tseymakh E.A., Zinchenko V.Yu., Lavrinenko O.Yu., Kalashnikov A.V., Shalabod E.A. 2024. The Use of Cryosupernatant Plasma Fraction in the Complex Treatment of Patients with Widespread Phlegmon of Soft Tissues Complicated by Sepsis. Bulletin of Medical Science. 1(33): 29–38 (in Russian). https://doi.org/10.31684/25418475-2024-1-29
Tseimakh E.A., Zinchenko V.Yu., Lavrinenko O.Yu., Chernenko V.V., Kalashnikov A.V., Shalabod E.A., Tseimakh M.E. 2022. Correction of Thrombohemorrhagic Syndrome in Patients with Widespread Soft Tissue Phlegmon and Sepsis. Research and Practical Medicine Journal. 9(1): 77–90 (in Russian). https://doi.org/10.17709/2410-1893-2022-9-1-7
Chirskii V.S., Andreeva E.A., Yuzvinkevich A.K., Gaivoronskii I.V. 2020. Pathomorphological Characteristics of Septic Shock in Modern Therapy. Journal of Anatomy and Histopathology. 9(1): 69–76 (in Russian). https://doi.org/10.18499/2225-7357-2020-9-1-69-76
Malykh M.S., Mellin R.V., Tiunova N.V., Ziatdinov B.R., Moiseev D.A., Tatarkin V.V., Karpova E.I., Vdovina L.V., Bakhmet A.A., Vasiliev Yu.L. 2024. Clinical and Anatomical Rationale for the Effectiveness of Treatment of Phlegmon of the Floor of the Oral Cavity and Deep Cellular Spaces of the Neck Complicated with Sepsis. Russian Journal of Operative Surgery and Clinical Anatomy. 8(2): 19–25 (in Russian). https://doi.org/10.17116/operhirurg2024802119
Iba T., Gando S., Saitoh D., Wada H., Di Nisio M., Thachil J. 2016. Antithrombin Supplementation and Risk of Bleeding in Patients with Sepsis-Associated Disseminated Intravascular Coagulation. Thromb. Res. 145: 46–50. https://doi.org/10.1016/j.thromres.2016.07.016
Levi M., Scully M. 2018. How I Treat Disseminated Intravascular Coagulation. Blood. 131(8): 845–854. doi:10.1182/blood-2017-10-804096