PROGNOSTIC VALUE OF ANEMIC SYNDROME IN SURGICAL PATIENTS WITH ELECTIVE SURGERY (REVIEW OF LITERATURE)
Anemic syndrome is a common pre-existing phenomenon among patients who are admitted to surgical hospitals for the purpose of elective surgery. The overall prevalence of it in the population increases with age, and in the elderly (>65 years), according to the data of World Health Organization, on average, reaches 11% and 10.2% for men and women, respectively. Thus, previously undiagnosed anemia is often found in patients who undergo elective surgery. Negative prognostic value of anemia for such patients is shown in a large number of foreign and a number of Russian studies. This review focuses on the effect of anemia on the prognosis of planned operations in patients with various surgical profiles. The review also considers the current state of the issue of correction of anemia and the effect of blood transfusions on the prognosis in these patients. The international consensus and recommendations for implementing the «patient blood management» strategy in surgical practice are discussed, which will reduce costs and improve the results of surgical intervention.
Kalyuta T.Y., Maslyakov V.V., Kazhekin O.A., Ilyasova T.A., Kochenkova O.V. 2020. Prognostic value of anemic syndrome in surgical patients with elective surgery (review of literature). Challenges in Modern Medicine, 43(1): 165–175 (in Russian). DOI
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1. Gorokhova S.G., Ryazhenov V.V., Emchenko I.V. 2013. Pharmacoeconomical evaluation of the effectiveness of iron preparations for the correction of anemia in the course of preparing patients for extensive planned surgical interventions. Conformal Ter., 22 (3): 47–52.
2. Kravchun P.G., Efremova O.A., Ryndina N.G., Titova A.Ju. 2013. Struktura anemicheskogo sindroma i osobennosti trofologicheskogo statusa u bol'nyh s hronicheskoj serdechnoj nedostatochnost'ju i hronicheskoj bolezn'ju pochek [Structure of anemic syndrome and features of trophological status in patients with chronic heart failure and chronic kidney disease]. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Serija: Medicina. Farmacija. 11 (154): 102–106.
3. Moiseev S.V. 2012. Iron carboxymaltose (Ferinject) – a new intravenous drug for the treat-ment of iron deficiency anemia. Klin Pharmacol Ter. 21 (2): 48–53.
4. Moiseev S.V. 2013. Effect of intravenous iron preparations on the need for blood transfu-sions in anemia. Klin Pharmacol Ter. 22 (5): 60–65.
5. Novik A.V. 2019. Anemia and metabolic disorders in cancer patients. Practical Oncology.10 (3): 131-40.
6. Rogachevsky O.V., Moiseev S.V. 2014. Clinical significance and treatment of anemia in the preoperative period. Clinical pharmacology and therapy. 23 (2): 55-60.
7. Ad N., Holmes S.D., Massimiano P.S., Spiegelstein D., Shuman D.J., Pritchard G., Halpin L. 2015. Operative risk and preoperative hematocrit in bypass graft surgery: Role of gender and blood trans-fusion. Cardiovasc. Revasc. Med. Oct.-Nov.;16 (7): 397–400.
8. Beris P., Muñoz M., García-Erce J.A., Thomas D., Maniatis A., Van der Linden P. 2008. Perioperative anaemia management: consensus statement on the role of intravenous iron. Br. J. Anaesth. 100 (5): 599–604.
9. Bisbe E., Basora M., Colomina M.J. 2017. Peri-operative treatment of anaemia in major or-thopaedic surgery: a practical approach from Spain. Spanish Best Practice in Peri-operative Anaemia Op-timisation Panel. Blood. Transfus. 15 (4): 296–306.
10. Bisbe Vives E. 2015. Treatment of preoperative anemia in major orthopedic surgery. Rev. Esp. Anestesiol. Reanim. 62 (1): 52–6.
11. Butcher A., Richards T. 2018. Cornerstones of patient blood management in surgery. Trans-fus. Med. 28 (2): 150–157.
12. Carson J.L., Duff A., Poses R.M., Berlin J.A., Spence R.K., Trout R., Noveck H., Strom B.L. 1996. Effect of anaemia and cardiovascular disease on surgical mortality and morbidity. Lancet; 348: 1055–60.
13. Carson J.L., Noveck H., Berlin J.A., Gould S.A. 2002. Mortality and morbidity in patients with very low postoperative Hb levels who decline blood transfusion. Transfusion. 42: 812–8.
14. Clevenger B., Richards T. 2015. Pre-operative anaemia. Anaesthesia. 2015 Jan; 70 Suppl. 1:20–8, e6–8.
15. Clevenger B., Mallett S.V., Klein A.A., Richards T. 2015. Patient blood management to re-duce surgical risk. Br. J. Surg. 102 (11): 1325–37.
16. Desai N., Schofield N., Richards T. 2018. Perioperative Patient Blood Management to Im-prove Outcomes. Anesth Analg. 127 (5): 1211–1220.
17. Ellermann I., Bueckmann A., Eveslage M., Buddendick H., Latal T., Niehoff D., Geis-sler R.G., Hempel G., Kerkhoff A., Berdel W.E., Roeder N., Van Aken H.K., Zarbock A., Steinbick-er A.U. 2018. Treating Anemia in the Preanesthesia Assessment Clinic: Results of a Retrospective Evalu-ation. Anesth. Analg. 127 (5): 1202–1210.
18. Goodnough L.T., Maniatis A., Earnshaw P., Benoni G., Beris P., Bisbe E., Fergusson D.A., Gombotz H., Habler O., Monk T.G., Ozier Y., Slappendel R., Szpalski M. 2011. Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines. Br. J. Anaesth. 106 (1): 13–22.
19. Goodnough L.T., Nissenson A.R., Dubois R.W. 2003. Anemia: not just an innocent bystand-er? Arch Intern Med, 163: 1400–4.
20. Guralnik J.M., Eisenstaedt R.S., Ferrucci L., Klein H.G., Woodman R.C. 2004. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood, 104: 2263–8.
21. Hogue C.W. Jr., Goodnough L.T., Monk T.G. 1998. Perioperative myocardial ischemic epi-sodes are related to hematocrit level in patients undergoing radical prostatectomy. Transfusion. 38: 924–31.
22. Kansagra A.J., Stefan M.S. 2016. Preoperative Anemia: Evaluation and Treatment. Anesthe-siol Clin. 34 (1): 127–41.
23. Kansagra A.J., Stefan M.S. 2016. Preoperative Anemia: Evaluation and Treatment. Anesthe-siol Clin. 34 (1): 127–41.
24. Kendoff D., Tomeczkowski J., Fritze J., Gombotz H., von Heymann C. 2011. Preoperative anemia in orthopedic surgery: clinical impact, diagnostics and treatment. Orthopade. 40 (11): 1018–20, 1023–5, 1027–8.
25. Kulier A., Levin J., Moser R., Rumpold-Seitlinger G., Tudor I.C., Snyder-Ramos S.A., Moehnle P., Mangano D.T. 2007. Impact of preoperative anemia on outcome in patients undergoing cor-onary artery bypass graft surgery. Investigators of the Multicenter Study of Perioperative Ischemia Re-search Group; Ischemia Research and Education Foundation. Circulation. 31;116 (5): 471–9.
26. LaPar D.J., Hawkins R.B., McMurry T.L., Isbell J.M., Rich J.B., Speir A.M., Quader M.A., Kron I.L., Kern J.A., Ailawadi G. 2018. Preoperative anemia versus blood transfusion: Which is the cul-prit for worse outcomes in cardiac surgery? Investigators for the Virginia Cardiac Services Quality Initia-tive. J. Thorac. Cardiovasc. Surg. 156 (1): 66–74.
27. Lasocki S., Krauspe R., von Heymann C., Mezzacasa A., Chainey S., Spahn D.R. 2015. PREPARE: the prevalence of perioperative anaemia and need for patient blood management in elective orthopaedic surgery: a multicentre, observational study. Eur. J. Anaesthesiol. 32 (3): 160–7.
28. Loor G., Rajeswaran J., Li L., Sabik J.F., Blackstone E.H., McCrae K.R., Koch C.G. 2013. The least of 3 evils: exposure to red blood cell transfusion, anemia, or both? J. Thorac. Cardiovasc. Surg. 146 (6): 1480–1487.
29. Melis M., McLoughlin J.M., Dean E.M., Siegel E.M., Weber J.M., Shah N., Kelley S.T., Karl R.C. 2009. Correlations between neoadjuvant treatment, anemia, and perioperative complications in patients undergoing esophagectomy for cancer. J. Surg. Res. 1:153 (1): 114–20.
30. Muñoz M., Acheson A.G., Auerbach M., Besser M., Habler O., Kehlet H., Liumbruno G.M., Lasocki S., Meybohm P., Rao Baikady R., Richards T., Shander A., So-Osman C., Spahn D.R., Klein A.A. 2017. International consensus statement on the peri-operative management of anaemia and iron deficiency. Anaesthesia. 72 (2): 233–247.
31. Muñoz M., Acheson A.G., Bisbe E., Butcher A., Gómez-Ramírez S., Khalafallah A.A., Kehlet H., Kietaibl S., Liumbruno G.M., Meybohm P., Rao Baikady R., Shander A., So-Osman C., Spahn D.R., Klein A.A. 2018. An international consensus statement on the management of postoperative anaemia after major surgical procedures. Anaesthesia. 73 (11): 1 418–1431.
32. Muñoz M., Gómez-Ramírez S., Kozek-Langeneker S. 2016. Pre-operative haematological assessment in patients scheduled for major surgery. Anaesthesia. 71 (1): 19–28.
33. Napolitano L.M. 2005. Perioperative anemia. Surg. Clin. North. Am. 85 (6): 1215–27.
34. Nutritional anaemias. Report of a WHO scientific group. World Health Organization Tech-nical Report Series No. 405. Geneva: World Health Organization, 1968.
35. Olson R.P., Stone A., Lubarsky D. 2005. The prevalence and significance of low preopera-tive hemoglobin in ASA 1 or 2 outpatient surgery candidates. Anesth. Analg. 101 (5): 1337–40.
36. Spiegelstein D., Holmes S.D., Pritchard G., Halpin L., Ad N. 2015. Preoperative hematocrit as a predictor of perioperative morbidities following nonemergent coronary artery bypass surgery. J. Card. Surg. 30 (1): 20–6.
37. Williams M.L., He X., Rankin J.S., Slaughter M.S., Gammie J.S. 2013. Preoperative hema-tocrit is a powerful predictor of adverse outcomes in coronary artery bypass graft surgery: a report from the Society of Thoracic Surgeons Adult Cardiac Surgery Database. Ann Thorac Surg. 96 (5): 1628–34.