Рrediction of Clinical Manifestations of Irritable Bowel Syndrome when Combined with Type 2 Diabetes Mellitus
The comorbidity of type 2 diabetes mellitus (DM) and irritable bowel syndrome (IBS) remain insufficiently studied. The aim of this study was to compare the clinical, laboratory and instrumental characteristics of patients with combination of IBS and type 2 DM with the clinical data of IBS and to develop criteria for predicting clinical manifestations of IBS in combination with type 2 DM on this basis. 107 patients with type 2 DM which have clinical manifestations of IBS were under observation. All patients were assessed for medical history and underwent a standard examinations. In addition, the levels of glycated hemoglobin, fructosamine, C-peptide, insulin, glucagon-like peptide-1 were assessed, the HOMA-IR and HOMA-B indices were calculated. As a result of the study, a number of statistically significant relationships between some clinical, laboratory and instrumental characteristics of patients and features of the clinical picture of IBS were identified. Based on the analysis of the data obtained, criteria for predicting the development of severe constipation syndrome, severe diarrhea syndrome and severe abdominal pain in patients with IBS and DM type 2 have been developed.
Suprun O.E., Bagriy A.E., Mikhailichenko E.S., Andreeva E.A., Yevtushenko A.A., Suprun E.V. 2024. Рrediction of Clinical Manifestations of Irritable Bowel Syndrome when Combined with Type 2 Diabetes Mellitus. Challenges in Modern Medicine, 47(1): 14–26 (in Russian). DOI: 10.52575/2687-0940-2024-47-1-14-26
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The work was carried out without external sources of funding.