Influence of interleukin-21 on the state of intracellular signaling mechanisms in leukocytes in patients with pneumonia
The results of a study of possible mechanisms of the influence of interleukin-21 on the functional state of blood cells and their production of cytokines in people who have had pneumonia are presented. Purpose: to study the effect of interleukin-21 on the state of signaling mechanisms, in particular, mitogen-activated / stress-activated signaling pathways, the level of heat shock proteins and histones in peripheral blood mononuclear leukocytes in community-acquired pneumonia convalescents, as well as the production of interleukins and growth factors. 40 male patients from 18 to 43 years old with community-acquired pneumonia on the 13–15th day of the disease were examined. Results. In persons who have had pneumonia, the level of interleukin-21 is associated with the state of mitogen-activated / stress-activated signaling pathways, as well as the signaling pathway associated with Janus kinases and signal transducers and transcription activators, determining the cytokine profile and features of the postclinical phase of the disease in such patients.
Bondar S.S., Terekhov I.V., Nikiforov V.S., Parfenyuk V.K., Bondar N.V. 2022. Effect of interleukin-21 on the state of intracellular signaling mechanisms in reconvalescents of pneumonia leukocytes and production of cytokines in community-acquired bacterial pneumonia. Challenges in Modern Medicine. 45 (1): 28–38 (in Russian). DOI: 10.52575/2687-0940-2022-45-1-28-38
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