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<article article-type="research-article" dtd-version="1.2" xml:lang="ru" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><front><journal-meta><journal-id journal-id-type="issn">2687-0940</journal-id><journal-title-group><journal-title>Актуальные проблемы медицины</journal-title></journal-title-group><issn pub-type="epub">2687-0940</issn></journal-meta><article-meta><article-id pub-id-type="doi">10.52575/2687-0940-2021-44-2-154-161</article-id><article-id pub-id-type="publisher-id">72</article-id><article-categories><subj-group subj-group-type="heading"><subject>ВНУТРЕННИЕ БОЛЕЗНИ</subject></subj-group></article-categories><title-group><article-title>&lt;strong&gt;Анализ интенсивности перекисного окисления липидов у пациентов с опытом работы в ночное время более 10 лет&lt;/strong&gt;</article-title><trans-title-group xml:lang="en"><trans-title>Analysis of the intensity of lipid peroxidation in patients with more than 10 years of experience working at night</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Грибанов</surname><given-names>Игорь Андреевич</given-names></name><name xml:lang="en"><surname>Gribanov</surname><given-names>Igor A.</given-names></name></name-alternatives><email>gribanov_doc@mail.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Зарубина</surname><given-names>Елена Григорьевна</given-names></name><name xml:lang="en"><surname>Zarubina</surname><given-names>Elena G.</given-names></name></name-alternatives></contrib></contrib-group><pub-date pub-type="epub"><year>2021</year></pub-date><volume>44</volume><issue>2</issue><fpage>0</fpage><lpage>0</lpage><self-uri content-type="pdf" xlink:href="/media/journal-medicine/2021/2/154-161.pdf" /><abstract xml:lang="ru"><p>34 пациентам мужского пола со средним возрастом в группе 40,3 &amp;plusmn; 0,9 лет, с опытом работы в ночное время более 10 лет, выполнена флуоресцентная спектроскопия. В качестве контроля использовали 25 лиц мужского пола со средним возрастом 40,2 &amp;plusmn; 1,2 без опыта работы в ночное время. Исследование проводилось с применением лазерного диагностического комплекса &amp;laquo;ЛАКК-М&amp;raquo; (&amp;laquo;ЛАЗМА&amp;raquo;, РФ) в режиме флуоресценция. У пациентов, работающих в ночное время свыше 10 лет, выявлено повышение активности перекисного окисления липидов (ПОЛ). Подобные нарушения тесно связаны с механизмами активации свободно радикальных реакций и могут становиться причиной развития многочисленных функциональных и морфологических нарушений в органах и тканях. Длительная работа в ночное время может приводить к интенсифакации ПОЛ. Характер выявленных нарушений ПОЛ и нарушение работы антиоксидантной системы организма на фоне длительной работы в ночное время позволяет предполагать их значимость в генезе развития нарушений обменных процессов на клеточном уровне.</p></abstract><trans-abstract xml:lang="en"><p>Fluorescence spectroscopy was performed in 34 male patients with an average age of 40.3 &amp;plusmn; 0.9 years in the group with more than 10 years of night work experience. 25 male patients with an average age of 40.2 &amp;plusmn; 1.2 years without night work experience were used as controls. The study was carried out using the laser diagnostic complex &amp;laquo;LAKK-M&amp;raquo; (&amp;laquo;LAZMA&amp;raquo;, RF), in the fluorescence mode. In patients working at night for more than 10 years, an increase in the activity of lipid peroxidation (POL) was detected. Such disorders are closely related to the mechanisms of activation of free radical reactions and can cause the development of numerous functional and morphological disorders in organs and tissues. Prolonged night work can lead to increased POL. The nature of the revealed violations of the LPO and the disruption of the antioxidant system of the body against the background of prolonged work at night allows us to assume their significance in the genesis of the development of metabolic disorders at the cellular level.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>перикисное окисление липидов</kwd><kwd>флуоресценция</kwd><kwd>работа в ночное время</kwd></kwd-group><kwd-group xml:lang="en"><kwd>lipid peroxidation</kwd><kwd>fluorescence</kwd><kwd>work at night</kwd></kwd-group></article-meta></front><back><ref-list><title>Список литературы</title><ref id="B1"><mixed-citation>Bhatti P., Mirick D.K., Randolph T.W., Gong J., Buchanan D.T., Zhang J.J., Davis S. 2017. 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