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<article article-type="research-article" dtd-version="1.2" xml:lang="ru" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><front><journal-meta><journal-id journal-id-type="issn">2687-0940</journal-id><journal-title-group><journal-title>Актуальные проблемы медицины</journal-title></journal-title-group><issn pub-type="epub">2687-0940</issn></journal-meta><article-meta><article-id pub-id-type="doi">10.52575/2687-0940-2025-48-1-15-28</article-id><article-id pub-id-type="publisher-id">226</article-id><article-categories><subj-group subj-group-type="heading"><subject>КАРДИОЛОГИЯ</subject></subj-group></article-categories><title-group><article-title>&lt;strong&gt;Механизмы развития аритмии при новой коронавирусной инфекции COVID-19&lt;/strong&gt;</article-title><trans-title-group xml:lang="en"><trans-title>&lt;strong&gt;Mechanisms of Arrhythmia Development in COVID-19&lt;/strong&gt; &lt;strong&gt;Patients&lt;/strong&gt;</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Камышникова</surname><given-names>Людмила Александровна</given-names></name><name xml:lang="en"><surname>Kamyshnikova</surname><given-names>Lyudmila A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Давыдова</surname><given-names>Ирина Викторовна</given-names></name><name xml:lang="en"><surname>Davydova</surname><given-names>Irina V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Гордиенко</surname><given-names>Юлия Андреевна</given-names></name><name xml:lang="en"><surname>Gordienko</surname><given-names>Yulia A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Байдук</surname><given-names>Диана Владимировна</given-names></name><name xml:lang="en"><surname>Baiduk</surname><given-names>Diana V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Прибылов</surname><given-names>Сергей Александрович</given-names></name><name xml:lang="en"><surname>Pribylov</surname><given-names>Sergey A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Паюдис</surname><given-names>Алексей Николаевич</given-names></name><name xml:lang="en"><surname>Payudis</surname><given-names>Alexey N.</given-names></name></name-alternatives></contrib></contrib-group><pub-date pub-type="epub"><year>2025</year></pub-date><volume>48</volume><issue>1</issue><fpage>0</fpage><lpage>0</lpage><self-uri content-type="pdf" xlink:href="/media/journal-medicine/2025/1/АПМ_т.48_1_2025_15-28.pdf" /><abstract xml:lang="ru"><p>Аритмия является частым сердечно-сосудистым осложнением у пациентов с новой коронавирусной инфекцией &amp;ndash; 2019 (COVID-19). Согласно проведенным исследованиям, частота аритмий колеблется от 16,7&amp;nbsp;% до 19,6&amp;nbsp;% среди госпитализированных пациентов с COVID-19. Целью данного обзора является изучение механизмов возникновения аритмии при COVID-19, для предоставления врачам комплексной основы для профилактики и лечения данных аритмий. Материалы и методы. Был проведен поиск статей за последние 5 лет в базах PubMed, Google Scholar и eLIBRARY по ключевым словам на русском и английском языках, статьи отбирались в соответствии с целью исследования. Результаты. Возникновение аритмий у пациентов с COVID-19 может быть связано с местными и системными воспалительными реакциями, вызванными вирусной инфекцией, приводящими к повреждению кардиомиоцитов, перикардиту, нарушению иммунного ответа, цитокиновым штормам, структурным изменениям в сердце и нарушениям сердечной проводимости, что в конечном итоге приводит к развитию аритмий. Но есть и другие факторы: нарушение электролитного баланса, ишемия/гипоксия миокарда, проаритмические побочные эффекты лекарств, используемых для лечения COVID-19, дисфункции вегетативной нервной системы. Заключение. Каждый из описанных механизмов развития аритмии влияет на другие механизмы, наибольшее число влияний имеют миокардит и нарушение регуляции иммунного ответа. Для профилактики аритмий, связанных с COVID-19, необходим контроль состояния основного заболевания, раннее выявление и лечение повреждения миокарда и других дисфункций органов, предотвращение гипоксии, предотвращение системного воспаления и уменьшение использования препаратов, удлиняющих интервал QT.</p></abstract><trans-abstract xml:lang="en"><p>Arrhythmia is a common cardiovascular complication in patients with the coronavirus disease 2019 (COVID-19). According to studies, the incidence of arrhythmia ranges from 16.7% to 19.6% among those hospitalized with COVID-19. The aim of this review is to study the mechanisms of arrhythmia occurrence in COVID-19 patients, to provide physicians with a comprehensive basis for the prevention and treatment of these arrhythmias. Materials and methods. A search was conducted for articles over the past 5 years in the PubMed, Google Scholar, and eLIBRARY databases by keywords in Russian and English, articles were selected in accordance with the purpose of the study. Results. The occurrence of arrhythmias in patients with COVID-19 may be associated with local and systemic inflammatory reactions caused by a viral infection, leading to damage to cardiomyocytes, pericarditis, impaired immune response, cytokine storms, structural changes in the heart and cardiac conduction disturbances, which ultimately leads to the development of arrhythmias. But there are also other factors: electrolyte imbalance, myocardial ischemia/hypoxia, proarrhythmic side effects of drugs used to treat COVID-19, dysfunction of the autonomic nervous system. Conclusion. Each of the described mechanisms of arrhythmia development influences other mechanisms, the greatest number of influences are: myocarditis and impaired regulation of the immune response. To prevent arrhythmias associated with COVID-19, it is necessary to monitor the underlying disease, provide early detection and treatment of myocardial damage and other organ dysfunctions, prevent hypoxia, prevent systemic inflammation and reduce the use of drugs that prolong the QT interval.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>аритмия</kwd><kwd>SARS-CoV-2</kwd><kwd>новая коронавирусная инфекция COVID-19</kwd><kwd>патогенез</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arrhythmia</kwd><kwd>SARS-CoV-2</kwd><kwd>COVID-19</kwd><kwd>pathogenesis</kwd></kwd-group></article-meta></front><back><ref-list><title>Список литературы</title><ref id="B1"><mixed-citation>Вишневский В.И., Панина Ю.Н., Вишневский М.В. 2022. Влияние дефицита электролитов на нарушения ритма сердца на фоне новой коронавирусной инфекции. 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