<?xml version='1.0' encoding='utf-8'?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd">
<article article-type="research-article" dtd-version="1.2" xml:lang="ru" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><front><journal-meta><journal-id journal-id-type="issn">2687-0940</journal-id><journal-title-group><journal-title>Актуальные проблемы медицины</journal-title></journal-title-group><issn pub-type="epub">2687-0940</issn></journal-meta><article-meta><article-id pub-id-type="doi">10.52575/2687-0940-2023-46-2-191-202</article-id><article-id pub-id-type="publisher-id">156</article-id><article-categories><subj-group subj-group-type="heading"><subject>СТОМАТОЛОГИЯ</subject></subj-group></article-categories><title-group><article-title>&lt;strong&gt;Анализ подходов к лечению стоматологических пациентов, принимающих антитромботическую терапию&lt;/strong&gt;</article-title><trans-title-group xml:lang="en"><trans-title>&lt;strong&gt;Analysis of Approaches to the Treatment of Patients Taking Antithrombotic Therapy&lt;/strong&gt;</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Халиме</surname><given-names>Ибрахим</given-names></name><name xml:lang="en"><surname>Halimeh</surname><given-names>Ibrahim</given-names></name></name-alternatives><email>dr.ibrahim.halimeh@icloud.com</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Мартиросян</surname><given-names>Cветлана Гариевна</given-names></name><name xml:lang="en"><surname>Martirosian</surname><given-names>Svetlana G.</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Беленова</surname><given-names>Ирина Александровна</given-names></name><name xml:lang="en"><surname>Belenova</surname><given-names>Irina A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Бут</surname><given-names>Людмила Владимировна</given-names></name><name xml:lang="en"><surname>But</surname><given-names>Lyudmila V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Проценко</surname><given-names>Наталия Алексеевна</given-names></name><name xml:lang="en"><surname>Protsenko</surname><given-names>Natalia A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Кудрявцев</surname><given-names>Олег Александрович</given-names></name><name xml:lang="en"><surname>Kudryavtsev</surname><given-names>Oleg A.</given-names></name></name-alternatives></contrib></contrib-group><pub-date pub-type="epub"><year>2023</year></pub-date><volume>46</volume><issue>2</issue><fpage>0</fpage><lpage>0</lpage><self-uri content-type="pdf" xlink:href="/media/journal-medicine/2023/2/191-202.pdf" /><abstract xml:lang="ru"><p>Лечение стоматологических пациентов, принимающих антитромботическую терапию (АТТ) и нуждающиеся в хирургическом лечении, является темой для споров среди сторонников различных подходов из-за отсутствия определенного стандарта ведения данных пациентов. При подготовке обзора были использованы электронные базы данных eLibrary, PubMed и Scopus. Выбор правильной тактики ведения стоматологических пациентов, находящихся на АТТ и нуждающихся в инвазивном вмешательстве, является актуальной проблемой как в России, так и во всем мире, т.&amp;nbsp;к. отсутствие достаточных знаний у стоматолога для оценки и сравнения риска тромбообразования и риска кровотечения, отсутствие протоколов лечения данных пациентов, отсутствие более тщательного сбора анамнеза и глубокого изучения проблемы могут привести к неблагоприятным сердечно-сосудистым событиям. Необходимо создание международных протоколов лечения стоматологических пациентов, принимающих АТТ, с учетом сопутствующих заболеваний, тромбоэмболического риска и риска кровотечений.</p></abstract><trans-abstract xml:lang="en"><p>For more than half a century, oral anticoagulants and antiplatelet therapy has been used to decrease and treat the risk of cardiovascular diseases. Patients taking antithrombotic therapy (ATT)may be at risk of excessive hemorrhage. For Dentists such patients, is a challenge since ATT is temporarily withdrawn to achieve adequate hemostasis at dental surgical manipulations, which increases the risk of thrombosis. For analysis was used: eLibrary, PubMed and Scopus electronic databases. Although there are clinical guidelines for the management of patients undergoing surgical procedures and who are receiving continuous ATT, not all have been designated for dentists and were extrapolated from general medicine. Furthermore, not all guidelines are up to date, and they often have missing information regarding the impact of new ATT agents on dental practice. So, It is necessary to create international protocols for the treatment of patients taking antithrombotic therapy, taking into account concomitant diseases, thromboembolic risk and risk of bleeding.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>антитромботическая терапия</kwd><kwd>кровотечение в хирургической стоматологии</kwd><kwd>двойная антитромбоцитарная терапия</kwd><kwd>удаление зубов</kwd><kwd>риск кровотечения</kwd><kwd>тромбоэмболический риск</kwd></kwd-group><kwd-group xml:lang="en"><kwd>antithrombotic therapy</kwd><kwd>bleeding in surgical dentistry</kwd><kwd>dual antiplatelet therapy</kwd><kwd>tooth extraction</kwd><kwd>risk of bleeding</kwd><kwd>thromboembolic risk</kwd></kwd-group></article-meta></front><back><ref-list><title>Список литературы</title><ref id="B1"><mixed-citation>Здравоохранение в России. 2021. Статистический сборник. Росстат. - Москва, 2021. &amp;ndash; 171 с.</mixed-citation></ref><ref id="B2"><mixed-citation>Котова Д.П., Шеменкова В.С. 2020. Принципы антитромботической терапии у пациентов в периоперационном периоде: что должен знать клиницист? Терапия. № 5. DOI: dx.doi.org/10.18565/therapy.2020.5.157-162</mixed-citation></ref><ref id="B3"><mixed-citation>Миронова А.И., Кропачева Е.С., Комлев А.Е., Макеев М.И., Имаев Т.Э., Панченко Е.П. 2021. Антитромботическая терапия у больных, нуждающихся в транскатетерной имплантации аортального клапана. Кардиологический вестник. 16&amp;nbsp;(3): 7&amp;ndash;14. doi.org/10.17116/Cardiobulletin2021160317</mixed-citation></ref><ref id="B4"><mixed-citation>Панченко Е.П., Комаров А.Л., Кропачева Е.С., Добровольский А.Б. 2020. Протокол ведения пациентов, нуждающихся в длительном приеме антитромботической терапии, при инвазивных вмешательствах. Кардиологический вестник 2: 63&amp;ndash;77 doi.org/10.36396/mS.2020.65.42.009</mixed-citation></ref><ref id="B5"><mixed-citation>Ткачева О.Н., Воробьёва Н.М., Котовская Ю.В., Рунихина Н.К., Стражеско И.Д., Виллевальде&amp;nbsp;С.В., Драпкина О.М., Комаров А.Л., Орлова Я.А., Панченко Е.П., Погосова&amp;nbsp;Н.В., Фролова Е.В., Явелов И.С. 2021.Антитромботическая терапия в пожилом и старческом возрасте: согласованное мнение экспертов Российской ассоциации геронтологов и гериатров и Национального общества профилактической кардиологии. Кардиоваскулярная терапия и&amp;nbsp;профилактика. 20 (3): 2847.&amp;nbsp;doi.org/10.15829/1728-8800-2021-2847</mixed-citation></ref><ref id="B6"><mixed-citation>Уддин Л.Н., Габитова М.А., Соколова А.А., Морозова Н.С., Напалков Д.А., Вычужанин Д.В., Егоров А.В., Фомин В.В. 2018. Сравнительная оценка различных схем периоперационной антикоагулянтной терапии у пациентов с фибрилляцией предсердий, нуждающихся в плановом хирургическом лечении. Кардиоваскулярная терапия и профилактика.17 (3): 71&amp;ndash;78. doi.org/10.15829/1728-8800-2018-3-71-78.</mixed-citation></ref><ref id="B7"><mixed-citation>Abayon M., Kolokythas A., Harrison S., Elad S. 2016. Dental management of patients on direct oral anticoagulants: Case series and literature review. Quintessence Int. 47&amp;nbsp;(8): 687&amp;ndash;96. doi: 10.3290/j.qi.a36325. PMID: 27574712.</mixed-citation></ref><ref id="B8"><mixed-citation>Al-Mohaissen M.A., Al-Mehisen R., Lee T., Al-Madi E.M. 2022. Managing Cardiac Patients: Dentists&amp;#39; Knowledge, Perceptions, and Practices. Int. Dent. J. 2022 Jun; 72&amp;nbsp;(3): 296&amp;ndash;307. doi: 10.1016/j.identj.2021.04.006.</mixed-citation></ref><ref id="B9"><mixed-citation>Chan N.C., Weitz J.I. Antithrombotic Agents. Circ. Res. 2019 Feb; 124&amp;nbsp;(3): 426&amp;ndash;436. doi: 10.1161/Circresaha.118.313155.</mixed-citation></ref><ref id="B10"><mixed-citation>Douketis J.D., Spyropoulos A.C., Murad M.H., Arcelus J.I., Dager W.E., Dunn A.S., Fargo R.A., Levy&amp;nbsp;J.H., Samama C.M., Shah S.H., Sherwood M.W., Tafur A.J., Tang L.V., Moores L.K. 2022. Perioperative Management of Antithrombotic Therapy: An American College of Chest Physicians Clinical Practice Guideline. Chest. Nov; 162&amp;nbsp;(5): e207-e243. doi: 10.1016/j.chest.2022.07.025</mixed-citation></ref><ref id="B11"><mixed-citation>Gaurav Verma, 2014. Dental Extraction Can Be Performed Safely in Patients on Aspirin Therapy: A Timely Reminde. Hindawi Publishing Corporation ISRN Dentistry. Volume 2014, Article ID 463684, 11 pages doi.org/10.1155/2014/463684</mixed-citation></ref><ref id="B12"><mixed-citation>Huang Jinxia, Liu Jie, Shi Haitao, Wu Jun, Liu Jiyuan, Pan Jian. 2022. Risk factors for bleeding after dental extractions in patients receiving antithrombotic drugs - A case control study, Journal of Dental Sciences, Volume 17, Issue 2, Pages 780&amp;ndash;786, ISSN 1991&amp;ndash;7902, doi.org/10.1016/j.jds.2021.10.005.</mixed-citation></ref><ref id="B13"><mixed-citation>Hornor Melissa, Duane Therese, Ehlers Anne, Jensen Eric, Brown Paul, Pohl Dieter, da Costa Paulo, Ko Clifford, Laronga Christine, 2018. American College of Surgeons&amp;rsquo; Guidelines for the Perioperative Management of Antithrombotic Medication. Journal of the American College of Surgeons 227&amp;nbsp;(5): p. 521&amp;ndash;536e1, November. | DOI: 10.1016/j.jamcollsurg.2018.08.183</mixed-citation></ref><ref id="B14"><mixed-citation>Kovacic J.C., Lee P., Karajgikar R., Baber U., Narechania B., Suleman J., Moreno P.R., Sharma S.K., Kini A.S. 2012. Safety of temporary and permanent suspension of antiplatelet therapy after drug eluting stent implantation in contemporary &amp;laquo;real-world&amp;raquo; practice. J. Interv. Cardiol. 2012 Oct; 25&amp;nbsp;(5): 482&amp;ndash;92. doi: 10.1111/j.1540-8183.2012.00746.x.</mixed-citation></ref><ref id="B15"><mixed-citation>Kovacs M.J., Wells P.S., Anderson D.R., Lazo-Langner A., Kearon C., Bates S.M., Blostein M., Kahn&amp;nbsp;S.R., Schulman S., Sabri E., Solymoss S., Ramsay T., Yeo E., Rodger M.A.; 2021 PERIOP2 Investigators. Postoperative low molecular weight heparin bridging treatment for patients at high risk of arterial thromboembolism (PERIOP2): double blind randomised controlled trial. BMJ. Jun 9;373:n1205. doi: 10.1136/bmj.n1205.</mixed-citation></ref><ref id="B16"><mixed-citation>Lewandowski B., Myszka A., Migut M., Czenczek-Lewandowska E., Brodowski R. 2021. Analysing the effectiveness of topical bleeding care following tooth extraction in patients receiving dual antiplatelet therapy-retrospective observational study. BMC Oral. Health. 21, 31. doi.org/10.1186/s12903-021-01391-9</mixed-citation></ref><ref id="B17"><mixed-citation>Lu Shin-Yu, Lin Liang-Ho, Hsue Shui-Sang, 2018. Management of dental extractions in patients on warfarin and antiplatelet therapy, Journal of the Formosan Medical Association, Volume 117,&amp;nbsp;Issue&amp;nbsp;11,&amp;nbsp;Pages&amp;nbsp;979&amp;ndash;986,&amp;nbsp;ISSN&amp;nbsp;0929-6646, doi.org/10.1016/j.jfma.2018.08.019</mixed-citation></ref><ref id="B18"><mixed-citation>Management of dental patients taking anticoagulants or antiplatelet drugs [Internet]. Dundee (Scotland): Scottish Dental Clinical Effectiveness Programme, 2022.</mixed-citation></ref><ref id="B19"><mixed-citation>Perry&amp;nbsp;D.,&amp;nbsp;Noakes,&amp;nbsp;T.&amp;nbsp;&amp;amp;&amp;nbsp;Helliwell&amp;nbsp;P.&amp;nbsp;2007.&amp;nbsp;Guidelines&amp;nbsp;for&amp;nbsp;the&amp;nbsp;management&amp;nbsp;of&amp;nbsp;patients&amp;nbsp;on&amp;nbsp;oral&amp;nbsp;anticoagulants&amp;nbsp;requiring&amp;nbsp;dentalsurgery.&amp;nbsp;British&amp;nbsp;dental&amp;nbsp;journal.&amp;nbsp;doi.org/10.1038/bdj.2007.892</mixed-citation></ref><ref id="B20"><mixed-citation>Precht C., Demirel Y., Assaf A.T., Pinnschmidt H.O., Knipfer C., Hanken H., Freinhard R.E., Wikner J. 2019. Perioperative management in patients with undergoing direct oral anticoagulant therapy in oral surgery &amp;ndash; A multicentric questionnaire survey. In Vivo. № 33 (3) 855&amp;ndash;862; DOI: doi.org/10.21873/invivo.11550</mixed-citation></ref><ref id="B21"><mixed-citation>Page M.J., McKenzie J.E., Bossuyt P.M., Boutron I., Hoffmann T.C., Mulrow C.D., Shamseer L., Tetzlaff J.M., Akl E.A., Brennan S.E., Chou R., Glanville J., Grimshaw J.M., Hr&amp;oacute;bjartsson A., Lalu&amp;nbsp;M.M., Li T., Loder E.W., Mayo-Wilson E., McDonald S., McGuinness L.A., Stewart L.A., Thomas J., Tricco A.C., Welch V.A., Whiting P., Moher D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 Mar 29; 372: n71. doi: 10.1136/bmj.n71.</mixed-citation></ref><ref id="B22"><mixed-citation>Park M.-W., Her S.H., Kwon J.B., Lee J.B., Choi M.S., Cho J.S., Kim D.B., Chung W.S., Seung K.B., Kim K.Y. 2012. Safety of dental extractions in coronary drug-eluting stenting patients without stopping multiple antiplatelet agents. Clin. Cardiol. Apr; 35&amp;nbsp;(4): 225&amp;ndash;30. doi: 10.1002/clc.21960. Epub 2012 Jan 25.</mixed-citation></ref><ref id="B23"><mixed-citation>Rodr&amp;iacute;guez L.A., Cea-Soriano L., Mart&amp;iacute;n-Merino E., Johansson S. 2011. Discontinuation of low dose aspirin and risk of myocardial infarction: case-control study in UK primary care. BMJ. Jul 19; 343:&amp;nbsp;d4094. doi: 10.1136/bmj.d4094.</mixed-citation></ref><ref id="B24"><mixed-citation>Tabrizi Rez, Isa Khaheshi, Afshin Hoseinzadeh, Babak Rezvanpour, and Shervin Shafie. 2018. Do Antiplatelet Drugs Increase the Risk of Bleeding After Dental Implant Surgery? A Case-and-Crossover Study. Journal of Oral and Maxillofacial Surgery. - 2018. - №&amp;nbsp;10. doi:.org/10.1016/j.joms.2018.04.036</mixed-citation></ref><ref id="B25"><mixed-citation>Watanabe N., Tanno K., Ito H., Onuki T., Miyoshi F., Minoura, Y., Kawamura M., Asano T., Katagiri T., &amp;amp; Kobayashi Y. 2012. Management of Patients Receiving Warfarin during Invasive Procedures and the Adverse Effects of Warfarin. Journal of Arrhythmia, 26 (2). doi: 10.1016/s1880-4276(10)80013-4</mixed-citation></ref></ref-list></back></article>