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<article article-type="research-article" dtd-version="1.2" xml:lang="ru" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><front><journal-meta><journal-id journal-id-type="issn">2687-0940</journal-id><journal-title-group><journal-title>Актуальные проблемы медицины</journal-title></journal-title-group><issn pub-type="epub">2687-0940</issn></journal-meta><article-meta><article-id pub-id-type="doi">10.52575/2687-0940-2022-45-1-39-54</article-id><article-id pub-id-type="publisher-id">104</article-id><article-categories><subj-group subj-group-type="heading"><subject>ВНУТРЕННИЕ БОЛЕЗНИ</subject></subj-group></article-categories><title-group><article-title>&lt;strong&gt;Клинические и патоморфологические паттерны диффузного альвеолярного поражения, обусловленного COVID-19, у пациентов, нуждающихся в респираторной поддержке&lt;/strong&gt;</article-title><trans-title-group xml:lang="en"><trans-title>&lt;strong&gt;Clinical and pathological patterns of diffuse alveolar damage due to COVID-19 in patients requiring respiratory support&lt;/strong&gt;</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Ходош</surname><given-names>Эдуард Михайлович</given-names></name><name xml:lang="en"><surname>Khodosh</surname><given-names>Eduard M.</given-names></name></name-alternatives><email>gen.khodosh@gmail.com</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Ивахно</surname><given-names>Игорь Владимирович</given-names></name><name xml:lang="en"><surname>Ivakhno</surname><given-names>Igor V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Ефремова</surname><given-names>Ольга Алексеевна</given-names></name><name xml:lang="en"><surname>Efremova</surname><given-names>Olga A.</given-names></name></name-alternatives><email>efremova@bsu.edu.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Оболонкова</surname><given-names>Наталья Ивановна</given-names></name><name xml:lang="en"><surname>Obolonkova</surname><given-names>Natalya I.</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Голивец</surname><given-names>Татьяна Павловна</given-names></name><name xml:lang="en"><surname>Golivets</surname><given-names>Tatyana P.</given-names></name></name-alternatives><email>golivets@ya.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Хамнагадаев</surname><given-names>Игорь Иосифович</given-names></name><name xml:lang="en"><surname>Khamnagadaev</surname><given-names>Igor I.</given-names></name></name-alternatives><email>efremova@bsu.ru</email></contrib></contrib-group><pub-date pub-type="epub"><year>2022</year></pub-date><volume>45</volume><issue>1</issue><fpage>0</fpage><lpage>0</lpage><self-uri content-type="pdf" xlink:href="/media/journal-medicine/2022/1/39-54.pdf" /><abstract xml:lang="ru"><p>Острый респираторный дистресс-синдром и дыхательная недостаточность являются основными угрожающими состояниями у больных COVID-19. Основной причиной является, прежде всего, нарушение перфузии легких. Неинвазивная вентиляция легких может устранить гипоксемию и снизить инспираторные усилия. Использование механической вентиляции для предотвращения самоиндуцированного повреждения легких (P-SILI) рассматривается как вариант оптимизации. Ведущей характеристикой прогрессирования COVID-19 является постепенный переход от отека или ателектаза к менее обратимым структурным изменениям легких, а именно к фиброзу. В итоге нарушается механика дыхания, повышается РСО2 в артериальной крови, снижается работа дыхательной мускулатуры и отсутствует реакция на положительное давление в конце выдоха в прон-позиции.</p></abstract><trans-abstract xml:lang="en"><p>Acute respiratory distress syndrome and respiratory failure are the main life-threatening conditions in patients with COVID-19. The main reason is, first of all, impaired lung perfusion. Non-invasive ventilation of the lungs can eliminate hypoxemia and reduce inspiratory efforts. The use of mechanical ventilation to prevent self-induced lung injury (P-SILI) is considered as an optimization option. The leading characteristic of the progression of COVID-19 is the gradual transition from edema or atelectasis to less reversible structural changes in the lungs, namely fibrosis. As a result, the mechanics of breathing is disturbed, PCO2 in the arterial blood rises, the work of the respiratory muscles decreases, and there is no response to positive pressure at the end of exhalation in the prone position.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>диффузное альвеолярное поражение</kwd><kwd>COVID-19</kwd><kwd>респираторная поддержка</kwd><kwd>сурфактант</kwd><kwd>острый респираторный дистресс-синдром</kwd><kwd>неинвазивная вентиляция легких</kwd></kwd-group><kwd-group xml:lang="en"><kwd>diffuse alveolar lesion</kwd><kwd>COVID-19</kwd><kwd>respiratory support</kwd><kwd>surfactant</kwd><kwd>acute respiratory distress syndrome</kwd><kwd>non-invasive lung ventilation</kwd></kwd-group></article-meta></front><back><ref-list><title>Список литературы</title><ref id="B1"><mixed-citation>WHO Director-General&amp;rsquo;s opening remarks at the media briefing on COVID-19 11 March 2020. 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