Список литературы

2687-0940

Актуальные проблемы медицины

2687-0940

10.52575/2687-0940-2021-44-4-460-470

100

ХИРУРГИЯ

<strong>Механизм воздействия молекулярного водорода в комплексном лечении ран мягких тканей и общей хирургической инфекции</strong>

<strong>Mechanism of exposure to molecular hydrogen in complex treatment of soft tissue wounds and general surgical infection</strong>

Андреев

Александр Алексеевич

Andreev

Alexander A.

Лаптиёва

Анастасия Юрьевна

Laptiyova

Anastasiya Yu.

laptievaa@mail.ru

Глухов

Александр Анатольевич

Glukhov

Alexander A.

Коняшин

Даниил Александрович

Konyashin

Daniil A.

Коновалов

Павел Андреевич

Konovalov

Pavel A.

Золотухин

Владимир Олегович

Zolotukhin

Vladimir O.

2021

44400

Молекулярный водород (МВ) достаточно давно известен как инертный газ, однако о его полезных свойствах стало известно только в 2007 году, когда были получены сведения о его антиоксидантных возможностях. Эффекты Н2 позволяют использовать его при комплексном лечении ран мягких тканей. В этом обзоре обсуждаются основные биологические действия, а также механизмы действия МВ при нарушениях целостности тканевых структур и септических повреждений органов со стороны основных способностей водорода: противоапоптических, противовоспалительных, антиоксидантных и аутофагических. Подробно описываются способы транспортировки, дозировки Н2, а также их достоинства и недостатки в практической медицине. Рассмотрены перспективы развития его внедрения в самые различные области лечения и основные проблемы, на которые до сих пор нет ответа.

Molecular hydrogen (MH) has been known for a long time as an inert gas, but its beneficial properties became known only in 2007, when information about its antioxidant capabilities was obtained. The effects of MH make it possible to use it in the complex treatment of soft tissue wounds. This review discusses the main biological actions, as well as the mechanisms of action of MH in violation of the integrity of tissue structures and septic damage to organs from the main abilities of hydrogen: anti-apoptotic, anti-inflammatory, antioxidant, and autophagic. The methods of transportation, dosage of H2, as well as their advantages and disadvantages in practical medicine are described in detail. The prospects for the development of its implementation in the most diverse areas of treatment and the main problems, which still have no answer, are considered.

молекулярный водородокислительный стрессраны мягких тканеймолекулярные механизмы

molecular hydrogenoxidative stresssoft tissue woundsmolecular mechanisms

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