Currently, much attention is paid to the study of the role of opportunistic microorganisms in systemic lupus erythematosus, researchers are increasingly interested in various aspects of their potential influence. The mechanisms of interaction of opportunistic microorganisms with the patient's immune system, contributing to the development and maintenance of chronic inflammation and autoimmunity, require further comprehensive research. Objective: to study the features of the humoral immune response to antigens of opportunistic microorganisms in patients with SLE. Clinical and laboratory examination of 26 patients with SLE and 30 conditionally healthy individuals of the control group was carried out. The level of IgG antibodies to the antigens of opportunistic bacteria was studied in the blood serum of the examined individuals by the ELISA method. Analysis of the presence of class G antibodies to opportunistic bacteria in the blood serum of patients with systemic lupus erythematosus revealed a more frequent detection of antibodies to the antigens of bacteria of the genus Streptococcus, S. aureus, E. coli, K. rpeimopiae compared with the control group. SLE patients had a statistically significantly higher level of IgG antibodies to the antigens of S. aureus, S. epidermidis, E. coli, and K. pneumoniae. The change in the level of antibodies characterizes the features of the antigenic load and confirms the presence of dysbiotic disorders in systemic lupus erythematosus, which should be taken into account when implementing optimal therapy.
Currently, much attention is paid to the study of the role of opportunistic microorganisms in systemic lupus erythematosus, researchers are increasingly interested in various aspects of their potential influence. The mechanisms of interaction of opportunistic microorganisms with the patient's immune system, contributing to the development and maintenance of chronic inflammation and autoimmunity, require further comprehensive research. Objective: to study the features of the humoral immune response to antigens of opportunistic microorganisms in patients with SLE. Clinical and laboratory examination of 26 patients with SLE and 30 conditionally healthy individuals of the control group was carried out. The level of IgG antibodies to the antigens of opportunistic bacteria was studied in the blood serum of the examined individuals by the ELISA method. Analysis of the presence of class G antibodies to opportunistic bacteria in the blood serum of patients with systemic lupus erythematosus revealed a more frequent detection of antibodies to the antigens of bacteria of the genus Streptococcus, S. aureus, E. coli, K. rpeimopiae compared with the control group. SLE patients had a statistically significantly higher level of IgG antibodies to the antigens of S. aureus, S. epidermidis, E. coli, and K. pneumoniae. The change in the level of antibodies characterizes the features of the antigenic load and confirms the presence of dysbiotic disorders in systemic lupus erythematosus, which should be taken into account when implementing optimal therapy.