2687-0940Challenges in modern medicine2687-094058INTERNAL DISEASES<strong>Clinical features of gastrointestinal tract damage in pations with new coronaviral infection COVID-19</strong><strong>Clinical features of gastrointestinal tract damage in pations with new coronaviral infection COVID-19</strong>TurchinaMaria S.TurchinaMaria S.turchina-57@mail.ruMishinaAlexandra S.MishinaAlexandra S.Sandra.mishina@bk.ruVeremeichikAlexey L.VeremeichikAlexey L.veremeichik.orel@yandex.ruReznikovRoman G.ReznikovRoman G.Reznikov.orel@yandex.ru202144100

Currently, schemes that include antibacterial drugs are used to treat a new coronavirus infection. In addition, medical workers themselves often prescribe massive antibiotic therapy to patients inappropriately, leading to an increase in antibiotic-associated diarrhea. In the case of patients with new coronavirus infection, this situation is complicated by the possibility of the virus directly infecting enterocytes and causing diarrhea. The presence of diarrhea in patients with COVID-19 significantly reduces the quality of life, aggravates the course of the disease, leading to an increase in the duration of disability, and can also cause death in the event of pseudomembranous colitis and severe dehydration. Considering all of the above, it is necessary to pay more attention to such patients, developing methods of treatment and prevention of gastrointestinal tract damage with diarrhea in a new coronavirus infection.

Currently, schemes that include antibacterial drugs are used to treat a new coronavirus infection. In addition, medical workers themselves often prescribe massive antibiotic therapy to patients inappropriately, leading to an increase in antibiotic-associated diarrhea. In the case of patients with new coronavirus infection, this situation is complicated by the possibility of the virus directly infecting enterocytes and causing diarrhea. The presence of diarrhea in patients with COVID-19 significantly reduces the quality of life, aggravates the course of the disease, leading to an increase in the duration of disability, and can also cause death in the event of pseudomembranous colitis and severe dehydration. Considering all of the above, it is necessary to pay more attention to such patients, developing methods of treatment and prevention of gastrointestinal tract damage with diarrhea in a new coronavirus infection.

SARS-CoV-2diarrheaantibiotic-associated diarrheaantibiotic therapySARS-CoV-2diarrheaantibiotic-associated diarrheaantibiotic therapy

the work was carried out with the support of the Department of Internal Diseases of the OSU named after I. S. Turgenev, as well as the BUZ OO &laquo;Polyclinic No. 3&raquo;.

Список литературыBaklaushev V.P., Kulemzin S.V., Gorchakov A.A., Jusubalieva G.M., Lesnjak V.N., Sotnikova A.G. 2020. COVID-19. Jetiologija, patogenez, diagnostika i lechenie [COVID-19. Etiology, pathogenesis, diagnostics and treatment]. Klinicheskaja praktika. 11 (1). 41 p.Zaharenko S.M., Andreeva I.V., Stecjuk O.U. 2019. Nezhelatel&#39;nye lekarstvennye reakcii so storony ZhKT i antibiotikoassociirovannaja diareja pri primenenii antibiotikov v ambulatornoj praktike: profilaktika i lechenie [Adverse drug reactions from the gastrointestinal tract and antibiotic-associated diarrhea in the use of antibiotics in outpatient practice: prevention and treatment]. Klinicheskaja mikrobiologija i antimikrobnaja himioterapija. 21: 3.Ivashkin V.T., Sheptulin A.A., Zol&#39;nikova O.Ju., Ohlobystin A.V., 2020. Polujektova E.A., Truhmanov A.S., Shirokova E.N., Gonik M.I., Trofimovskaja N.I. Novaja koronavirusnaja infekcija (COVID-19) i sistema organov pishhevarenija [New coronavirus infection (COVID-19) and the digestive system]. Rossijskij zhurnal gastrojenterologii, gepatologii, koloproktologii. 30 (3): 7&ndash;13.Maev I.V., Shpektor A.V., Vasil&#39;eva E.Ju., Manchurov V.N., Andreev D.N. 2020. Novaja koronavirusnaja infekcija COVID-19: jekstrapul&#39;monal&#39;nye projavlenija [New coronavirus infection COVID-19: extrapulmonary manifestations]. Terapevticheskij arhiv. 92 (8): 22 p.Mashkovskij M.D. 2017. Lekarstvennye sredstva [Medicinal products]. M.: Umerenkov, Novaya volna, 117&ndash;120 p.; 189&ndash;192 p.Sarsenbaeva A.S., Lazebnik L.B. 2020. Diareja pri COVID-19 u vzroslyh [Diarrhea with COVID-19 in adults]. Jeksperimental&#39;naja i klinicheskaja gastrojenterologija. 6: 42&ndash;54.Cheung K.S., Hung I.F., Chan P.P., Lung K.C., Tso E., Liu R., Ng Y.Y., Chu M.Y., Chung T.W., Tam A.R., Yip C.C., Leung K., Fung A.Y., Zhang R.R., Lin Y., Cheng H.O., Zhang A.J., Kelvin K.W., Chan K., Yuen K., Leung W.K. 2020. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from the Hong Kong cohort and systematic review and meta-analysis. Gastroenterology. 93 с.D&#39;Amico F., Baumgart D.C., Danese S., Peyrin-Biroulet L. 2020. Diarrhea during COVID-19 infection: pathogenesis, epidemiology, prevention and management. Clinical Gastroenterology and Hepatology. 4.Hoffmann M., Kleine-Weber H., Schroeder S., Kr&uuml;ger N., Herrler T., Erichsen S., Schiergens T., Herrler G., Wu N.H., Nitsche A., M&uuml;ller M.A, Drosten C., P&ouml;hlmann S. 2020. SARSCoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 15.Hung Y.P., Lee J.C, Tsai B.Y, Wu J.L., Liu H.C, Liu S.C, Lin H.J, Tsai P.J ,Ko W.R. 2019. Risk factors of Clostridium difficile-associated diarrhea in hospitalized adults: Vary by hospitalized duration. Journal of Microbiology, Immunology and Infection. 11.Jonsdottir H.R., Dijkman R. 2016. Coronaviruses and the human airway: a universal system for virus-host interaction studies. Virology journal. 13 (1): 1&ndash;9.Lin L., Jiang X., Zhang Z., Huang S., Zhang Z., Fang Z., Gu Z., Gao L., Shi H., Mai L., Liu Y., Lin X., Lai R., Yan Z., Li X., Shan H. 2020. Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection. Gut. 69 (6): 997&ndash;1001.Monteleone G., Ardizzone S. 2020.Are patients with inflammatory bowel disease at increased risk for Covid-19 infection? Journal of Crohn&#39;s and Colitis.Song Y., Liu P., Shi X.L., Chu J.L., Zhang J., Xia J. 2020. SARS-CoV-2 induced diarrhea as onset symptom in patient with COVID-19. Gut. 69 (6): 1143&ndash;1144.Wei X., Wang X., Niu Y., Ye L., Peng W., Wang Z., Yang W., Yang B., Zhang J., Ma W., Wang X., Zhou Q. 2020. Diarrhea is associated with prolonged symptoms and viral carriage in COVID-19. Clinical Gastroenterology and Hepatology. 37 с.Wei X.S., Wang X., Niu Y.R., Ye L.L., Peng W.B., Wang Z.H., Yang W.B., Yang B.H., Zhang J.C., Ma W.L., Wang, X.R. 2020. Clinical characteristics of SARS-CoV-2 infected pneumonia with diarrhea. Available at SSRN 3546120. 8 с.Ye Q., Wang B., Mao J. 2020. The pathogenesis and treatment of the Cytokine Storm in COVID-19. Journal of infection. 80 (6): 607&ndash;613.Ye Q., Wang B., Zhang T., Xu J. 2020. Shiqiang Shang The mechanism and treatment of gastrointestinal symptoms in patients with COVID-19. American Journal of Physiology-Gastrointestinal and Liver Physiology. 319 (2): 245&ndash;252.Zhu N., Zhang D., Wang W., Li X., Yang B., Song G., Zhao X., Huang B., Shi W., Lu R., M.D., Niu P., Zhan F. 2020. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 382 (8): 727&ndash;733.