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<article article-type="research-article" dtd-version="1.2" xml:lang="ru" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><front><journal-meta><journal-id journal-id-type="issn">2687-0940</journal-id><journal-title-group><journal-title>Challenges in modern medicine</journal-title></journal-title-group><issn pub-type="epub">2687-0940</issn></journal-meta><article-meta><article-id pub-id-type="doi">10.18413/2687-0940-2020-43-1-65-72</article-id><article-id pub-id-type="publisher-id">5</article-id><article-categories><subj-group subj-group-type="heading"><subject>CARDIOLOGY</subject></subj-group></article-categories><title-group><article-title>&lt;strong&gt;MODERN ASPECTS OF TREATMENT OF PATIENTS WITH ATRIAL FIBRILLATION WITH NEW ORAL ANTICOAGULANTS&lt;/strong&gt;</article-title><trans-title-group xml:lang="en"><trans-title>&lt;strong&gt;MODERN ASPECTS OF TREATMENT OF PATIENTS WITH ATRIAL FIBRILLATION WITH NEW ORAL ANTICOAGULANTS&lt;/strong&gt;</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Vishnevskij</surname><given-names>Valery I.</given-names></name><name xml:lang="en"><surname>Vishnevskij</surname><given-names>Valery I.</given-names></name></name-alternatives><email>vishnevsky.orel@mail.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Panina</surname><given-names>Yulia N.</given-names></name><name xml:lang="en"><surname>Panina</surname><given-names>Yulia N.</given-names></name></name-alternatives><email>doc.panina@yandex.ru</email></contrib></contrib-group><pub-date pub-type="epub"><year>2020</year></pub-date><volume>43</volume><issue>1</issue><fpage>0</fpage><lpage>0</lpage><self-uri content-type="pdf" xlink:href="/media/journal-medicine/2020/1/65-72.pdf" /><abstract xml:lang="ru"><p>The review article describes current aspects of the use of new oral anticoagulants in patients with AF. Weaknesses and strengths of anticoagulants are considered. The questions of anticoagulants administration to patients with valvular and non-valvular atrial fibrillation are considered. Particular attention is paid to stratifying the risk of thromboembolism in atrial fibrillation. A comparison of new oral anticoagulants and warfarin is given. Modern new oral anticoagulants registered in the Russian Federation are described. The features of the use of drugs in patients with liver pathology, acute coronary syndrome, and renal failure are considered. Aspects of administration of new oral anticoagulants in patients with atrial fibrillation during cardioversion are considered. The principles of transferring patients from one anticoagulant to another are considered. The provided approaches can help practitioners in choosing the most acceptable and rational management scheme for a patient with AF.</p></abstract><trans-abstract xml:lang="en"><p>The review article describes current aspects of the use of new oral anticoagulants in patients with AF. Weaknesses and strengths of anticoagulants are considered. The questions of anticoagulants administration to patients with valvular and non-valvular atrial fibrillation are considered. Particular attention is paid to stratifying the risk of thromboembolism in atrial fibrillation. A comparison of new oral anticoagulants and warfarin is given. Modern new oral anticoagulants registered in the Russian Federation are described. The features of the use of drugs in patients with liver pathology, acute coronary syndrome, and renal failure are considered. Aspects of administration of new oral anticoagulants in patients with atrial fibrillation during cardioversion are considered. The principles of transferring patients from one anticoagulant to another are considered. The provided approaches can help practitioners in choosing the most acceptable and rational management scheme for a patient with AF.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>atrial fibrillation</kwd><kwd>thromboembolism</kwd><kwd>ischemic stroke</kwd><kwd>new oral anticoagulants</kwd><kwd>rivaroxaban</kwd><kwd>dabigatran</kwd><kwd>apixaban</kwd></kwd-group><kwd-group xml:lang="en"><kwd>atrial fibrillation</kwd><kwd>thromboembolism</kwd><kwd>ischemic stroke</kwd><kwd>new oral anticoagulants</kwd><kwd>rivaroxaban</kwd><kwd>dabigatran</kwd><kwd>apixaban</kwd></kwd-group></article-meta></front><back><ref-list><title>Список литературы</title><ref id="B1"><mixed-citation>1. Bokarev I.N., Kondrat&amp;#39;eva T.B. 2016. Novye oral&amp;#39;nye antikoaguljanty v klinichskoj praktike. Jeffektivnost&amp;#39; i problemy [New oral anticoagulants in medicine practice. Efficiency and problems]. 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