Objective. The study is focused on exploring the relationship between irritable bowel syndrome (IBS) and the development of liver fibrosis in patients with chronic persistent hepatitis, as well as evaluating the role of IBS as a potential factor in the progression of this disease. Materials and Methods. We examined 69 patients aged 18–59 years, including 36 men (52 %) and 33 women (48 %), with chronic persistent hepatitis (CPH). The patients were divided into two groups: Group 1, 35 patients with CPH combined with irritable bowel syndrome (IBS); Group 2, 34 patients with CPH without IBS. The instrumental methods used for the study included ultrasound diagnostics of the abdominal organs. To achieve the study's objectives, the degree of liver fibrosis was determined using transient elastography with the LFP-5 transducer of the Mindray Hepatus 6 ultrasound system. Fibrosis was assessed using the METAVIR scale. Results. The study revealed a statistically significant pattern: patients with chronic hepatic pulmonary disease (CHP) combined with IBS significantly more often exhibited more pronounced pathological changes in the hepatobiliary system. The ultrasound detection rate of liver damage in patients with comorbid pathology (CHP + IBS) was 1.9 times higher than in patients with isolated CHP. Conclusions. The presence of comorbid pathology in the form of irritable bowel syndrome in patients with chronic persistent hepatitis can serve as a marker of an increased risk of liver disease progression and requires more careful monitoring using instrumental methods, primarily ultrasound, for the timely diagnosis of complications.