2687-0940Challenges in modern medicine2687-094010.52575/2687-0940-2026-49-1-77-85279STOMATOLOGY<strong>The Effect of Glucocorticosteroids on the Osseointegration of Dental Implants: Pathogenetic Mechanisms and Clinical Consequences</strong><strong>The Effect of Glucocorticosteroids on the Osseointegration of Dental Implants: Pathogenetic Mechanisms and Clinical Consequences</strong>BayramzadeFiruza Sh.BayramzadeFiruza Sh.IvanovSergey Yu.IvanovSergey Yu.syivanov@yandex.ruMuraevAmir A.MuraevAmir A.202649100

Glucocorticosteroids (GCS) have a complex effect on bone metabolism, theoretically creating risks for dental implant osseointegration through glucocorticoid-induced osteoporosis (GIOP). Aim: to analyze the pathogenetic mechanisms of GCS effect on bone remodeling around dental implants and assess clinical consequences. Materials and methods: an analytical literature review was conducted in PubMed, Scopus, and eLibrary databases (2018&ndash;2025) using keywords: glucocorticoids, osseointegration, dental implants, osteoporosis. Results: pathogenetic mechanisms (suppressed osteogenesis, increased resorption, inhibited angiogenesis) create serious theoretical risks. However, clinical studies demonstrate that with careful treatment planning (two-stage protocol, adequate integration period) GCS intake does not preclude high success rates (up to 99 % osseointegration). Conclusions: long-term GCS therapy is not an absolute contraindication for dental implantation. Risk minimization strategies include bone metabolism assessment, pharmacological correction, osteoinductive implant surfaces, and careful monitoring.

Glucocorticosteroids (GCS) have a complex effect on bone metabolism, theoretically creating risks for dental implant osseointegration through glucocorticoid-induced osteoporosis (GIOP). Aim: to analyze the pathogenetic mechanisms of GCS effect on bone remodeling around dental implants and assess clinical consequences. Materials and methods: an analytical literature review was conducted in PubMed, Scopus, and eLibrary databases (2018&ndash;2025) using keywords: glucocorticoids, osseointegration, dental implants, osteoporosis. Results: pathogenetic mechanisms (suppressed osteogenesis, increased resorption, inhibited angiogenesis) create serious theoretical risks. However, clinical studies demonstrate that with careful treatment planning (two-stage protocol, adequate integration period) GCS intake does not preclude high success rates (up to 99 % osseointegration). Conclusions: long-term GCS therapy is not an absolute contraindication for dental implantation. Risk minimization strategies include bone metabolism assessment, pharmacological correction, osteoinductive implant surfaces, and careful monitoring.

glucocorticosteroidsosseointegrationdental implantsbone remodelingglucocorticoid-induced osteoporosisglucocorticosteroidsosseointegrationdental implantsbone remodelingglucocorticoid-induced osteoporosisСписок литературыBrudyan G.R., Khabibulina M.M., Strukov V.I., Ivanov S.Y., Muraev A.A. 2023. Osseointegration of Dental Implants in Menopausal Osteoporosis: Optimization Strategies, Ways and Prospects for Solving the Problem. Physician. 7: 80&ndash;86 (in Russian). doi: 10.29296/25877305-2023-07-18Guzov S.A., Ostapovich A.A., Ivashenko S.V. 2021. Patomorphological Changes in Bone Tissue around Dental Implants after Stimulation of their Osseointgration. Innovations and Actual Problems of Morphology: Collection of Scientific Articles / under General ed. N.A. Trushel. Minsk. P. 107&ndash;110.Krasivina I.G., Dolgova L.N., Dolgov N.V., Larina A.A. 2019. Pathogenesis and Prevention of Glucocorticoid-induced Osteoporosis. Medical Council. 21: 45&ndash;52 (in Russian). doi: 10.21518/2079-701X-2019-21-126-134Kulakov A.A., Kasparov A.S., Porfenchuk D.A. 2019. Factors Affecting Osseointegration and the Use of Early Functional Loading to Reduce Treatment Time in Dental Implantation. Dentistry. 98(4): 107&ndash;115 (in&nbsp;Russian). doi: 10.17116/stomat201998041107Al Subaie A., Emami E. Signaling Pathways of Dental Implants&#39; Osseointegration: The Race for the Future. BDJ Open. 2024; 10(1): 29. doi: 10.1038/s41405-024-00211-wCho S.K., Sung Y.K. 2021. Update on Glucocorticoid Induced Osteoporosis. Endocrinology and Metabolism (Seoul). 36(3): 536&ndash;543. doi: 10.3803/EnM.2021.1021.Chotiyarnwong P., McCloskey E.V. 2020. Pathogenesis of Glucocorticoid-Induced Osteoporosis and Options for Treatment. Nature Reviews Endocrinology. 16: 437&ndash;447. doi: 10.1038/s41574-020-0341-0Compston J., Cooper A., Cooper C., Gittoes N., Gregson C., Harvey N., Hope S., Kanis J.A., McCloskey E.V., Poole K.E.S., Reid D.M., Selby P., Thompson F., Thurston A., Vine N. 2017. UK Clinical Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis. Rheumatology (Oxford). 56(9): 1485&ndash;1486. doi: 10.1093/rheumatology/kex222D&#39;Ambrosio F., Amato A., Chiacchio A., Sisalli L., Giordano F. 2023. Do Systemic Diseases and Medications Influence Dental Implant Osseointegration and Dental Implant Health? An Umbrella Review. Dentistry Journal. 11(6): 146. doi: 10.3390/dj11060146Di Antonio A., Castagnetti R., D&#39;Agostino A., De Angelis P., Frezza A., Pellegrino G. 2023. Do Systemic Diseases and Medications Influence Dental Implant Osseointegration and Dental Implant Health? An Umbrella Review. Dentistry Journal. 11(6): 146. doi: 10.3390/dj11060146Fazliu V., Gashi-Rizaj A., Krasniqi Y., Bimbashi V. 2024. The Impact of Systemic Drugs on Dental Implant Osseointegration: A Review. Georgian Medical News. 349: 31&ndash;35.Guarnotta V., Di Stefano C., Tomasello L., Maniscalco L., Pizzolanti G., Arnaldi G., Giordano C. 2024. Conventional Steroids vs. Dual-Release Hydrocortisone on Metabolic, Cardiovascular, and Bone Outcomes in Adrenal Insufficiency: A 10-Year Study. European Journal of Endocrinology. 191(3): 300&ndash;311. doi: 10.1093/ejendo/lvae107Hasenmajer V., Ferrari D., De Alcubierre D., Sada V., Puliani G., Bonaventura I., Minnetti M., Tomaselli A., Pofi R., Sbardella E., Cozzolino A., Gianfrilli D., Isidori A.M. 2023. Effects of Dual-Release Hydrocortisone on Bone Metabolism in Primary and Secondary Adrenal Insufficiency: A 6-Year Study. Journal of the Endocrine Society. 8(1): 151. doi: 10.1210/jendso/bvad151Kou Y., Rong X., Tang R., Zhang Y., Yang P., Liu H., Ma W., Li M. 2023. Eldecalcitol Prevented OVX Induced Osteoporosis through Inhibiting BMSCs Senescence by Regulating the SIRT1-Nrf2 Signal. Front Pharmacol. 14: 1067085. doi: 10.3389/fphar.2023.1067085Lee S., Remark L.H., Josephson A.M., Leclerc K., Lopez E.M., Kirby D.J., Mehta D., Litwa H.P., Wong M.Z., Shin S.Y., Leucht P. 2021. Notch-Wnt Signal Crosstalk Regulates Proliferation and Differentiation of Osteoprogenitor Cells During Intramembranous Bone Healing. NPJ Regenerative Medicine. 6(1): 29. doi: 10.1038/s41536-021-00139-xLee Y.J., Kim S.Y., Yoon K.J., Kim K.S. 2025. Impact of Osteoporosis on Dental Implant Survival, Failure and Marginal Bone Loss: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 14(19): 6719. doi: 10.3390/jcm14196719Li C., Xue P., Duan G., Wang H., Zhang Y., Li M. 2025. ED-71 Promotes Osseointegration of Titanium Implants in a Rat Model of GIOP by Alleviating the Effects of Dexamethasone on Bone Remodeling in a SIRT1-Dependent Manner. Journal of Oral Biosciences. 67(1): 100571. doi: 10.1016/j.job.2024.10.003Ma Y., Wang S., Wang H., Chen X., Shuai Y., Wang H., Mao Y., He F. 2023. Mesenchymal Stem Cells and Dental Implant Osseointegration during Aging: From Mechanisms to Therapy. Stem Cell Research and Therapy. 14(1): 382. doi: 10.1186/s13287-023-03611-1Mohammadi A., Dehkordi N.R., Mahmoudi S., Mahmoudi M., Gholami M., Mohammadi M. 2023. Effects of Drugs and Chemotherapeutic Agents on Dental Implant Osseointegration: A Narrative Review. Current Reviews in Clinical and Experimental Pharmacology. 19(1): 42&ndash;60. doi: 10.2174/2772432817666220607114559Petsinis V., Kamperos G., Alexandridi F., Alexandridis K. 2017. The Impact of Glucocorticosteroids Administered for Systemic Diseases on the Osseointegration and Survival of Dental Implants Placed without Bone Grafting &ndash; A Retrospective Study in 31 Patients. Journal of Cranio-Maxillofacial Surgery. 45(8): 1197&ndash;1200. doi: 10.1016/j.jcms.2017.03.010Rabczak Z., Kasprzak K., Kuczek M., Wiśniewska A., Marek J., Jasiński M., Szalach M., Narloch M. 2025. Long-term Effects of Dental Implants in Patients with Osteoporosis &ndash; A Literature Review. International Journal of Innovative Technologies in Social Science. 4(48): 1&ndash;9. doi: 10.31435/ijitss.4(48).2025.4081Romanos G.E., Ciornei G., Jucan A., Malmstrom H., Gupta B. 2014. In vitro Assessment of Primary Stability of Straumann Implant Designs. Clinical Implant Dentistry and Related Research. 16(1): 89&ndash;95. doi: 10.1111/j.1708-8208.2012.00464.xSagheb K., Yildirimturk S., Kaya S., Fan S., Morlock M., Sagheb K. 2025. Ex vivo Comparison of Drilling Techniques for Optimizing Primary Stability of Zirconia Dental Implants in Different Bone Densities. International Journal of Implant Dentistry. 11(1): 28. doi: 10.1186/s40729-025-00603-zXu C., Wei Z., Liu N., Wang X., Wang X. 2015. The Effect of Implant Shape and Screw Pitch on Microdamage in Mandibular Bone. Clinical Implant Dentistry and Related Research. 17(2): 365&ndash;372. doi: 10.1111/cid.12100Yu S., Li D., Zhang N., Ni S., Sun M., Wang L., Xiao H., Liu D., Liu J., Yu Y., Zhang Z., Yeung S.T.Y., Zhang S., Lu A., Zhang Z., Zhang B., Zhang G. 2022. Drug Discovery of Sclerostin Inhibitors. Acta Pharm Sin B. 12(5): 2150&ndash;2170. doi: 10.1016/j.apsb.2022.01.012