This article presents the results of research conducted in 2018–2019 on the basis of LLC «SSB of the Dental clinic of Starooskolsky district». Methods of rapid adaptation of patients after prosthetics with removable structures against the background of reduced immunity have been developed and described. Prevention and treatment is based on a comprehensive approach to treatment, using a soft base material «Ufigel» and immunomodulating drug «Imudon». The study involved 40 patients (20 men and 20 women) aged 45 to 70 years with secondary partial or complete adentia. The first group included patients who were conditionally healthy and had their first orthopedic treatment with removable prostheses. In group 2 patients, concomitant somatic diseases and chronic stomatitis were detected during the collection of anamnesis. For these patients, a soft UFI gel pad was used. Group 3 included patients with chronic diseases of the oral cavity, which, in the adaptation period of 30 days, took an immunomodulating drug as prescribed «Imudon», and also used a soft pad. The reaction of the prosthetic bed mucosa was evaluated (on the 3, 7 and 27 days). The research presented in the article should increase the level of orthopedic treatment with removable structures. The influence of the immunomodulator «Imudon» and soft padding material «Ufigel» on the adaptation period in patients with removable structures, against the background of reduced immunity, was studied.