In recent years, statistics have shown a stable mortality rate from acute pancreatitis, which is fixed at around 3 %. At the same time, the analysis of postoperative outcomes indicates that the mortality rate after surgery varies from 9.3 % to 9.6 %. The purpose of the study. To determine the role of changes in ferritin concentration in the diagnosis of the severity of acute pancreatitis. Materials and methods. As part of the scientific research, a prospective assessment of clinical cases was carried out with a one-time coverage of a contingent of patients diagnosed with acute pancreatitis with a variable severity of the pathological process. Three subgroups of patients were identified: mild, moderate, and severe. Patients with moderate and severe degrees were admitted in the early phase, so two additional periods were allocated: IA and IB. The clinical comparison group included patients with an established diagnosis of chronic pancreatitis. The patients of the study group and the clinical comparison group underwent blood sampling in the first 2 hours after hospitalization with determination of serum ferritin concentration by the immunochemiluminescent method (IHL) using Access Ferritin reagents from Beckman Culter USA. Statistical processing of the obtained results was carried out using the SPSS Statistics 20.0 program. Conclusions. It was found that in patients with acute pancreatitis, ferritin concentration increases in direct proportion to the severity, reaching a maximum value in the subgroup of patients with severe 879.6 ± 321.7 mg/l. It was revealed that in the early phase in period B, the average ferritin concentration reaches a maximum value of 879.6 ± 150.9 mg/l. This protein, which is an indicator of inflammation, can be used as an additional marker to assess the severity of acute pancreatitis and serve as a criterion for predicting the development of complications. This allows for more informed decisions about treatment tactics and the intensity of monitoring the patient's condition.
In recent years, statistics have shown a stable mortality rate from acute pancreatitis, which is fixed at around 3 %. At the same time, the analysis of postoperative outcomes indicates that the mortality rate after surgery varies from 9.3 % to 9.6 %. The purpose of the study. To determine the role of changes in ferritin concentration in the diagnosis of the severity of acute pancreatitis. Materials and methods. As part of the scientific research, a prospective assessment of clinical cases was carried out with a one-time coverage of a contingent of patients diagnosed with acute pancreatitis with a variable severity of the pathological process. Three subgroups of patients were identified: mild, moderate, and severe. Patients with moderate and severe degrees were admitted in the early phase, so two additional periods were allocated: IA and IB. The clinical comparison group included patients with an established diagnosis of chronic pancreatitis. The patients of the study group and the clinical comparison group underwent blood sampling in the first 2 hours after hospitalization with determination of serum ferritin concentration by the immunochemiluminescent method (IHL) using Access Ferritin reagents from Beckman Culter USA. Statistical processing of the obtained results was carried out using the SPSS Statistics 20.0 program. Conclusions. It was found that in patients with acute pancreatitis, ferritin concentration increases in direct proportion to the severity, reaching a maximum value in the subgroup of patients with severe 879.6 ± 321.7 mg/l. It was revealed that in the early phase in period B, the average ferritin concentration reaches a maximum value of 879.6 ± 150.9 mg/l. This protein, which is an indicator of inflammation, can be used as an additional marker to assess the severity of acute pancreatitis and serve as a criterion for predicting the development of complications. This allows for more informed decisions about treatment tactics and the intensity of monitoring the patient's condition.