The aim of the experiment was to analyze the characteristics of behavioral reactions and the intensity of regeneration in the post-traumatic period in small animals. Materials and methods. The experiment involved mature male rats of the breed Vistar (Rappolovo vivarius), weighing 180–320 gr. and aged from six to twelve months. Injury simulation was performed by precision impactor, followed by behavioral responses (PR) on infrared activometer for two weeks. Results and discussion.  By the 14th day, the behavioral reactions (PR) in small animals of the first group remained close to reference values, in the second group locomotor activity was sharply reduced, in the third group back-leg rise in response to sound signal was not recorded, while in the  fourth group locomotor activity (LA) and the stereotype (S) of behavior was 1.8 times lower than in the other three groups. Conclusion. The damage to the small animals' snout bones in the early post-traumatic period is characterized by negative dynamics of PR.  A reduction of motor activity has been recorded, which is most likely due to the disruption of brain and neuro-humoral activity. The study revealed a metabolic imbalance, with a reduced amount of food and water consumed despite their availability, which most likely stems from disruptions in the brain and neuro-humoral activity. Control CT of the second and the fourth group showed signs of occificate deficit in the injured tissues. Morphologically, it corresponded to the local regeneration disturbances.