Studying the levels of biomarkers of inflammation and surfactant protein D (SDP) in the peripheral blood of patients with chronic obstructive pulmonary disease (COPD) depending on the nutritional status (NS) of patients is relevant, since they are important factors in the progression of the disease. Aim. To study the relationship between tumor necrosis factor-α (TNF-α), transforming growth factor β1 (TGFβ1), C-reactive protein (CRP), surfactant protein D (SPD) and NS in patients with COPD. Materials and methods. 210 patients with COPD with different body mass index (BMI) were examined. Laboratory, instrumental (spirography, bioimpedansometry, pulse oximetry), spectrophotometric and immunoenzyme research methods were used. Results. It is shown that in patients with COPD during an exacerbation of the disease, regardless of NS, there is an increase in the levels of TNFα, TGFβ1, CRP, as well as SDP in the blood serum, which is most pronounced when COPD is combined with obesity. A moderate correlation has been established between the level of SDP in the blood serum and the duration of smoking, as well as between SDP and BMI in patients with COPD; a negative correlation has been established between the level of SDP and indicators of external respiratory function. Conclusion. The degree of increase in serum levels of TNF-α, TGFβ1 and CRP directly correlates with concomitant obesity in patients with COPD. The level of SDP in COPD depends on the patient’s NS and can serve as a diagnostic marker of the disease. Multivariate analysis confirms the dependence of the level of SDP in the blood serum on the parameters of bioimpedance analysis in COPD.