Список литературы

2687-0940

Challenges in modern medicine

2687-0940

10.52575/2687-0940-2024-47-1-14-26

179

INTERNAL DISEASES

<strong>Рrediction of Clinical Manifestations of Irritable Bowel Syndrome when Combined with Type 2 Diabetes Mellitus</strong>

Suprun

Oleg E.

Suprun

Oleg E.

alex.ponomarenko31415@gmail.com

Bagriy

Andrey E.

Bagriy

Andrey E.

Mikhailichenko

Evgeniia S.

Mikhailichenko

Evgeniia S.

Andreeva

Elena A.

Andreeva

Elena A.

Yevtushenko

Alexandra A.

Yevtushenko

Alexandra A.

Suprun

Evgeniy V.

Suprun

Evgeniy V.

2024

47100

The comorbidity of type 2 diabetes mellitus (DM) and irritable bowel syndrome (IBS) remain insufficiently studied. The aim of this study was to compare the clinical, laboratory and instrumental characteristics of patients with combination of IBS and type 2 DM with the clinical data of IBS and to develop criteria for predicting clinical manifestations of IBS in combination with type 2 DM on this basis. 107 patients with type 2 DM which have clinical manifestations of IBS were under observation. All patients were assessed for medical history and underwent a standard examinations. In addition, the levels of glycated hemoglobin, fructosamine, C-peptide, insulin, glucagon-like peptide-1 were assessed, the HOMA-IR and HOMA-B indices were calculated. As a result of the study, a number of statistically significant relationships between some clinical, laboratory and instrumental characteristics of patients and features of the clinical picture of IBS were identified. Based on the analysis of the data obtained, criteria for predicting the development of severe constipation syndrome, severe diarrhea syndrome and severe abdominal pain in patients with IBS and DM type 2 have been developed.

diabetes mellitusirritable bowel syndromeconstipationdiarrheaabdominal painpsychoemotional stressCOVID-19

The work was carried out without external sources of funding.

Список литературы

Andreev D.N., Dicheva D.T. 2019. Optimizacija lechenija pacientov s sindromom razdrazhennogo kishechnika: fokus na povyshenie komplaentnosti. [Optimizing the Treatment of Patients with Irritable Bowel Syndrome: Focus on Increased Compliance] Medicinskij sovet. 3: 118–124. doi: 10.21518/2079-701X-2019-3-118-124

Bagrij A.Е., Shukina E.V., Efremenko V.A., Mikhailichenko E.S., Suprun E.V. 2021. Sovremennye medikamentoznye podhody k kontrolju glikemii u bol'nyh saharnym diabetom 1 i 2 tipov [Modern Drug Approaches to Glycemic Control in Patients with Type 1 and Type 2 Diabetes Mellitus]. Farmateka. 28(4): 74–95. doi: 10.18565/pharmateca.2021.4.69-75

Gaus O.V., Livzan M.A. 2023. Fenotipy sindroma razdrazhennogo kishechnika i strategii pacientoorientirovannoj kuracii bol'nogo [Phenotypes of Irritable Bowel Syndrome and Strategies for Patient-Oriented Curation of Patient]. Lechashhij Vrach. 7–8: 36–44. doi:10.51793/OS.2023.26.8.006

Gaus O.V., Livzan M.A. 2021 Sindrom razdrazhennogo kishechnika: chto novogo? (Obzor materialov UEG Week Virtual 2020). [Irritable Bowel Syndrome: What's New?] Medicinskij alfavit. 1(6): 41–47. doi:10.33667/2078-5631-2021-6-41-47

Dedov I.I., Shestakova M.V., Majorov A.Ju., Shamhalova M.Sh., Suhareva O.Ju., Galstjan G.R., Tokmakova A.Ju., Nikonova T.V., Surkova E.V., Kononenko I.V., Egorova D.N., Ibragimova L.I., Shestakova E.A., Klefortova I.I., Skljanik I.A., Jarek-Martynova I.Ja., Severina A.S., Martynov S.A., Vikulova O.K., Kalashnikov V.Ju., Bondarenko I.Z., Gomova I.S., Rozhivanov R.V., Starostina E.G., Ametov A.S., Anciferov M.B., Bardymova T.P., Bondar' I.A., Valeeva F.V., Demidova T.Ju., Kiseleva T.P., Klimontov V.V.,Mkrtumjan A.M., Petunina N.A., Rujatkina L.A., Suplotova L.A., Ushakova O.V., Halimov Ju.Sh. 2022. Saharnyj diabet 2 tipa u vzroslyh (Klinicheskie Rekomendacii) [Diabetes Mellitus Type 2 in Adults] Saharnyj diabet. 23(S2): 4–251. doi:10.14341/DM12507

Ivashkin I.T., Ivashkin V.T., Maev I.V., Shelygin Yu.A., Baranskaya E.K., Belous S.S., Belousova E.A., Beniashvili A.G., Vasilyev S.V., Veselov A.V., Grigoryev E.G., Kostenko N.V., Kashnikov V.N., Kulikovskiy V.F., Loranskaya I.D., Lyashenko O.S., Poluektova E.A., Rumyantsev V.G., Timerbulatov V.M., Fomenko O.Yu., Khubezov D.A., Chashkova E.Yu., Chibisov G.I., Shapina M.V., Sheptulin A.A., Shifrin O.S., Trukhmanov A.S., Alekseeva O.P., Alekseenko S.A., Baranovsky A.Yu., Zolnikova O.Yu., Korochanskaya N.V., Mammayev S.N., Khlynov I.B., Tsukanov V.V. 2022. Diagnostika i lechenie sindroma razdrazhennogo kishechnika (Klinicheskie rekomendacii Rossijskoj gastrojenterologicheskoj associacii i Associacii koloproktologov Rossii) [Clinical Recommendations of the Russian Gastroenterological Association and Association of Coloproctologists of Russia]. Rossijskij Zhurnal Gastrojenterologii, Gepatologii, Kolonoproktologii. 31(5): 74–95.  doi: 10.22416/1382-4376-2021-31-5-74-95

Ignatenko G.A., Bagriy A.E., Prikolota O.A., Prikolota A.V., Mogilevskaya K.E. 2022. Saharnyj diabet: rukovodstvo dlja vrachej. [Diabetes Mellitus: a Guide for Physicians] Donetsk, RB Pozitiv.

Maev I.V., Samsonov A.A., Dicheva D.T., Kuznetsova Ye.I, Shcherbakova N.A., Akselrod A.G., Shakh Yu.S. 2019. Kliniko-funkcional'nye narushenija verhnih otdelov pishhevaritel'nogo trakta u bol'nyh saharnym diabetom 2-go tipa [Upper Digestive Tract Clinic and Functional Disorders in Patients with Type 2 Diabetes]. Jeffektivnaja farmakoterapija. 15(18): 10–14. doi: 10.33978/2307-3586-2019-15-18-10-14

Petri A., Sabin K. 2021. Nagljadnaja medicinskaja statistika [Medical Statistics at a Glance]. Moskva, Gjeotar-Media.

Truhan D.I., Ivanova D.S., Trukhan L.Yu. 2021. Gastrojenterologicheskie problemy pacientov s saharnym diabetom [Gastroenterological Problems of Patients with Diabetes Mellitus] FOCUS Jendokrinologija. 3: 52–61. doi: 10.47407/ef2021.2.3.0035

Shestakova M.V., Vikulova O.K., Zheleznyakova A.V., Isakov M.A., Dedov I.I. 2019. Jepidemiologija saharnogo diabeta v Rossijskoj Federacii: chto izmenilos' za poslednee desjatiletie? [Epidemiology of Diabetes Mellitus in the Russian Federation: What Has Changed Over the Last Decade]. Terapevticheskij arhiv. 91(10): 4–13. doi: 10.26442/00403660.2019.10.000364

Shumilova, N.A., Pavlova S.I. 2019. Glifloziny: glikemicheskie i neglikemicheskie jeffekty [Glyphosine Derivatives: Glycemic and Non-Clycemic Effects]. Acta medica Eurasica.1: 44–51.

American Diabetes Association. 4. 2020 Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes – 2020. Diabetes care. 43(1): S7–47. doi: 10.2337/dc20-S004

American Diabetes Association. 5. 2020. Facilitating Behavior Change and Well-Being to Improve Health Outcomes: Standards of Medical Care in Diabetes – 2020. Diabetes Care. 43(1): S48-65. doi: 10.2337/dc20-S005

American Diabеtes Association. ADA 2021 Standards of Medical Care in Diabetes – 2021. Diabetes Care. 44(1): 1–232. doi: 10.2337/dc21-S001. doi: 10.2337/dc21-S002

Arasaradnam R.P., Brown S., Forbes A., Fox M.R., Hungin P., Kelman L., Major G., O’Connor M., Sanders D.S., Sinha R., Smiths S.C., Thomas P., Walters J.R.F. 2018. Guidelines for the Investigation of Chronic Diarrhoea in Adults: British Society of Gastroenterology, 3rd Edition. Gut. 67: 1380–1399. doi: 10.1136/gutjnl-2017-315909

Bajaj A. 2020. The Variable Portability – Irritable Bowel Syndrome. EC Gastroenterology and Digestive system.7(2): 1–9.

Barberio В., Houghton L.A., Yiannakou Y., Savarino E., Black C.J., Ford A.C. 2021. Symptom Stability in Rome IV vs Rome III Irritable Bowel Syndrome. The American Journal of Gastroenterology. 116(2): Р. 362–371. doi: 10.14309/ajg.0000000000000946

Chedid V., Brandler J., Vijayvargiya P., Park S., Szarka L.A., Camilleri M. 2019. Characterization of Upper Gastrointestinal Symptoms, Gastric Motor Functions, and Associations in Patients with Diabetes at a Referral Center. Official Journal of the American College of Gastroenterology. ACG. 114(1): 143–154. doi: 10.1038/s41395-018-0234-1

Garber А.J., Handelsman Y., Grunberger G., Einhorn D., Abrahamson M.J., Barzilay J.I., Blonde L., Bush M.A., DeFronzo R.A., Garber J.R., Garvey W.T., Hirsch B., Jellinger P.S., McGill J.B., Mechanick J.I., Perreault L., Rosenblit P.D., Samson S., Umpierrez G.E. 2020. Consensus Statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the Comprehensive Type 2 Diabetes Management Algorithm. Endocrine Practice. 26(1): 107–139. doi: 10.4158/CS-2019-0472

Sommers Т., Mitsuhashi S., Singh P., Hirsch W., Katon J., Ballou S., Rangan V., Cheng V., Friedlander D., Iturrino J., Lembo A., Nee J. 2019. Prevalence of Chronic Constipation and Chronic Diarrhea in Diabetic Individuals in the United States. Official Journal of the American College of Gastroenterology. ACG. 114(1): 135–142. doi: 10.1038/s41395-018-0418-8

Vijayvargiya Р., Camilleri M., Chedid V., Mandawat A., Erwin P.J., Murad M.H. 2019. Effects of Promotility Agents on Gastric Emptying and Symptoms: a Systematic Review and Meta-Analysis. Gastroenterology. 156(6): 1650–1660. doi: 10.1053/j.gastro.2019.01.249