In the course of the study, the authors carried out a comparative analysis of the chemical composition, direction of action and cost of adhesives Compofix (ortho) (RF) and Enlight (USA) in dental practice, in the orthodontic treatment of patients. The key result of the research was the proof of the competitiveness of the 5th generation domestic adhesive in comparison with the American counterpart, not only in terms of cost, but also the comparability of action during the treatment of patients. The authors used a sample of 34 patients who had received orthodontic treatment. Based on the results of the analysis and price calculations, the cost of orthodontic treatment using metal braces and the Compofix (ortho) adhesive system (Russia) is 2 times lower than using the American Enlight system, while the price of a domestic adhesive is practically, 3 times lower than the foreign price, which contributes to the strengthening of the technological sovereignty of the industrial production of medical devices and technologies in Russia.