Acute mesenteric ischemia is a rare, but also life-threatening pathology that is still unresolved controversial emergency surgery problem. Nowadays we have seen an increase of disease in recent years along with a lack of single general management of the patients which impacts the high mortality. Therefore, this topic is relevant and interesting to study. With the development of medicine, the views and approaches to surgery are changing. But is everything so simple with modern opportunities and in the era of minimally invasive surgery? This disease requires urgent diagnosis and immediate treatment for the successful outcome. That’s why it should be worked out every step at the stage of treatment without unnecessary hesitation and time delay. In this article we tried to put together and present an update of acute mesenteric ischemia and diversified guidelines for diagnosis and treatment. Perhaps the secret of success in the fight against the disease lies in prevention.