For more than half a century, oral anticoagulants and antiplatelet therapy has been used to decrease and treat the risk of cardiovascular diseases. Patients taking antithrombotic therapy (ATT)may be at risk of excessive hemorrhage. For Dentists such patients, is a challenge since ATT is temporarily withdrawn to achieve adequate hemostasis at dental surgical manipulations, which increases the risk of thrombosis. For analysis was used: eLibrary, PubMed and Scopus electronic databases. Although there are clinical guidelines for the management of patients undergoing surgical procedures and who are receiving continuous ATT, not all have been designated for dentists and were extrapolated from general medicine. Furthermore, not all guidelines are up to date, and they often have missing information regarding the impact of new ATT agents on dental practice. So, It is necessary to create international protocols for the treatment of patients taking antithrombotic therapy, taking into account concomitant diseases, thromboembolic risk and risk of bleeding.