Currently, the use of steam cocktails when smoking is becoming very popular. Many are switching to electronic cigarettes, steam cocktails (hookah), as they believe that they do not harm the body. The aim of the work is to study the biochemical composition of saliva in persons using steam cocktails when smoking tobacco. A survey of 60 patients with different smoking experience was conducted. For the purposes of the study, there were three groups: group 1 – smoking experience less than five years, group 2 – smoking experience more than five years, control group – non-smokers. For a biochemical study of saliva, and specifically saliva thiocyanates, ferric chloride must be added to saliva. After that, a complete compound is formed, which contains thiocyanate and iron. As a result of the study, 60 patients were examined. In the first group (smoking experience less than five years) 20 patients, in the second group (smoking experience more than five years) – 20 patients, in the control group (non-smokers) – 20 patients. The study revealed that in groups 1 and 2 the amount of thiocyanate increases significantly. The results of a study that was carried out show that in persons using steam cocktails while smoking, the amount of thiocyanate in saliva is significantly higher than in non-smokers.