This article describes a clinical case of observation and treatment of a patient after a severe form of a new coronavirus infection. The condition was accompanied by a long symptomatic period (post-COVID period), a decrease in a number of objective criteria, and gross structural disorders detected by tomography. The logic of choice and the experience of using various drugs and their combinations for the treatment of a post-COVID state are described. Of particular interest and relevance is the observation of the use of a number of agents with potential and proven antifibrotic properties. Changes in the dynamics of computed tomography data are presented and discussed. Such situations cause significant difficulties in the work of specialists related to the rehabilitation of post-COVID patients. To date, the tactics of their treatment does not have a single approach. The description of this case can be useful in the work of general practitioners, pulmonologists, etc.