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<article article-type="research-article" dtd-version="1.2" xml:lang="ru" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><front><journal-meta><journal-id journal-id-type="issn">2687-0940</journal-id><journal-title-group><journal-title>Challenges in modern medicine</journal-title></journal-title-group><issn pub-type="epub">2687-0940</issn></journal-meta><article-meta><article-id pub-id-type="doi">10.52575/2687-0940-2022-45-4-319-324</article-id><article-id pub-id-type="publisher-id">128</article-id><article-categories><subj-group subj-group-type="heading"><subject>INTERNAL DISEASES</subject></subj-group></article-categories><title-group><article-title>&lt;strong&gt;Clinical Case of Rheumatoid Seronegative Polyarthritis Against the Background of Latent Tuberculosis Infection&lt;/strong&gt;&lt;br /&gt;
&amp;nbsp;</article-title><trans-title-group xml:lang="en"><trans-title>&lt;strong&gt;Clinical Case of Rheumatoid Seronegative Polyarthritis Against the Background of Latent Tuberculosis Infection&lt;/strong&gt;&lt;br /&gt;
&amp;nbsp;</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Fentisov</surname><given-names>Vitaly V.</given-names></name><name xml:lang="en"><surname>Fentisov</surname><given-names>Vitaly V.</given-names></name></name-alternatives><email>fentisov@bsuedu.ru</email></contrib></contrib-group><pub-date pub-type="epub"><year>2022</year></pub-date><volume>45</volume><issue>4</issue><fpage>0</fpage><lpage>0</lpage><self-uri content-type="pdf" xlink:href="/media/journal-medicine/2022/4/319-324_pYiiZQS.pdf" /><abstract xml:lang="ru"><p>A clinical example of a combined pathology of rheumatoid arthritis and latent tuberculosis infection is presented. Before being included in the program of genetically engineered biological therapy for rheumatoid arthritis, immunological screening for the presence of latent tuberculosis infection was carried out. Properly organized immunological diagnosis of tuberculosis in tuberculosis risk groups contributed to the early detection of a patient with latent tuberculosis infection. The preventive course of anti-tuberculosis therapy made it possible to start treatment of rheumatoid arthritis with immunosuppressive pills, reducing the risk of activation of tuberculosis infection.</p></abstract><trans-abstract xml:lang="en"><p>A clinical example of a combined pathology of rheumatoid arthritis and latent tuberculosis infection is presented. Before being included in the program of genetically engineered biological therapy for rheumatoid arthritis, immunological screening for the presence of latent tuberculosis infection was carried out. Properly organized immunological diagnosis of tuberculosis in tuberculosis risk groups contributed to the early detection of a patient with latent tuberculosis infection. The preventive course of anti-tuberculosis therapy made it possible to start treatment of rheumatoid arthritis with immunosuppressive pills, reducing the risk of activation of tuberculosis infection.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>rheumatoid arthritis</kwd><kwd>genetically engineered biological therapy</kwd><kwd>latent tuberculosis infection</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rheumatoid arthritis</kwd><kwd>genetically engineered biological therapy</kwd><kwd>latent tuberculosis infection</kwd></kwd-group></article-meta></front><back><ref-list><title>Список литературы</title><ref id="B1"><mixed-citation>References</mixed-citation></ref><ref id="B2"><mixed-citation>Artemiev A. A. 2017. Vliyaniye defektov vedeniya bol&amp;#39;nykh v obshchey lechebnoy seti na formirovaniye lekarstvennoy ustoychivosti MBT [The influence of defects in patient management in the general medical network on the formation of MBT drug resistance]. 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