Acute agranulocytosis is a rare, potentially life-threatening condition that is associated with taking medications in more than 70 % of cases. Agranulocytosis is characterized by the number of peripheral neutrophils < 0.5 × 109/l. Currently, due to the widespread use of cytotoxic therapy in medical practice, as well as the emergence of a large number of new pharmacological agents, the frequency of cases of agranulocytosis has increased significantly. Although this pathology can be found quite rarely (1 case per 1 200 people), its manifestations in the oral cavity such as ulcerative-necrotic gingivitis and stomatitis, herpetic rashes, necrosis of the tonsils, tooth mobility are a serious problem for a dentist involved in the treatment of this disease. This article will consider a clinical case of acquired agranulocytosis of a young patient against the background of taking thyrostatics, with vivid manifestations of the disease in the oral cavity. Treatment and diagnosis were carried out conscientiously by hematologists, endocrinologists and dentists, based on examination, complaints, careful collection of anamnesis and the results of additional studies. Despite the fact that acquired agranulocytosis is a rather rare disease, the described algorithms of the work carried out, supported by a photoprotocol and the results of treatment, will be relevant for dentists of all specialties, for the formation of clinical thinking and observation.
Acute agranulocytosis is a rare, potentially life-threatening condition that is associated with taking medications in more than 70 % of cases. Agranulocytosis is characterized by the number of peripheral neutrophils < 0.5 × 109/l. Currently, due to the widespread use of cytotoxic therapy in medical practice, as well as the emergence of a large number of new pharmacological agents, the frequency of cases of agranulocytosis has increased significantly. Although this pathology can be found quite rarely (1 case per 1 200 people), its manifestations in the oral cavity such as ulcerative-necrotic gingivitis and stomatitis, herpetic rashes, necrosis of the tonsils, tooth mobility are a serious problem for a dentist involved in the treatment of this disease. This article will consider a clinical case of acquired agranulocytosis of a young patient against the background of taking thyrostatics, with vivid manifestations of the disease in the oral cavity. Treatment and diagnosis were carried out conscientiously by hematologists, endocrinologists and dentists, based on examination, complaints, careful collection of anamnesis and the results of additional studies. Despite the fact that acquired agranulocytosis is a rather rare disease, the described algorithms of the work carried out, supported by a photoprotocol and the results of treatment, will be relevant for dentists of all specialties, for the formation of clinical thinking and observation.