<?xml version='1.0' encoding='utf-8'?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd">
<article article-type="research-article" dtd-version="1.2" xml:lang="ru" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><front><journal-meta><journal-id journal-id-type="issn">2687-0940</journal-id><journal-title-group><journal-title>Challenges in modern medicine</journal-title></journal-title-group><issn pub-type="epub">2687-0940</issn></journal-meta><article-meta><article-id pub-id-type="doi">10.52575/2687-0940-2022-45-2-178-197</article-id><article-id pub-id-type="publisher-id">116</article-id><article-categories><subj-group subj-group-type="heading"><subject>STOMATOLOGY</subject></subj-group></article-categories><title-group><article-title>&lt;strong&gt;Conservative treatment of inflammatory periodontal diseases in young, middle-aged and elderly patients: current aspects&lt;/strong&gt;</article-title><trans-title-group xml:lang="en"><trans-title>&lt;strong&gt;Conservative treatment of inflammatory periodontal diseases in young, middle-aged and elderly patients: current aspects&lt;/strong&gt;</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Oleinik</surname><given-names>Yelena A.</given-names></name><name xml:lang="en"><surname>Oleinik</surname><given-names>Yelena A.</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Oleinik</surname><given-names>Olga I.</given-names></name><name xml:lang="en"><surname>Oleinik</surname><given-names>Olga I.</given-names></name></name-alternatives><email>dr.olgaoleynik@yandex.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Sudareva</surname><given-names>Anastasiya V.</given-names></name><name xml:lang="en"><surname>Sudareva</surname><given-names>Anastasiya V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Markosyan</surname><given-names>Zaruy S.</given-names></name><name xml:lang="en"><surname>Markosyan</surname><given-names>Zaruy S.</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Belenova</surname><given-names>Irina A.</given-names></name><name xml:lang="en"><surname>Belenova</surname><given-names>Irina A.</given-names></name></name-alternatives></contrib></contrib-group><pub-date pub-type="epub"><year>2022</year></pub-date><volume>45</volume><issue>2</issue><fpage>0</fpage><lpage>0</lpage><self-uri content-type="pdf" xlink:href="/media/journal-medicine/2022/2/178-197_M6mGKPJ.pdf" /><abstract xml:lang="ru"><p>The paper focuses on current techniques and tools for conservative treatment of inflammatory periodontal diseases including ultrasound systems, antiseptic, antibacterial, anti-inflammatory and reparative medicinal products. These techniques and tools can be applied for treatment of diverse pathological conditions and combined with other types of treatment (orthopedic and surgical). The paper presents outcomes of modern research studies investigating etiopathogenetic aspects of periodontal pathology to understand features of complex therapy. It also covers issues of application of nature-based products: phytopreparations, polysaccharide-based products containing hyaluronic acid. As stated various physical factors have a beneficial effect on periodontal tissues depending on the nature of their action. Their differentiated application combined with pharmaceuticals allows purposefully influencing various components of the etiology and pathogenesis to treat gingivitis and periodontitis in young, middle-aged and elderly patients.</p></abstract><trans-abstract xml:lang="en"><p>The paper focuses on current techniques and tools for conservative treatment of inflammatory periodontal diseases including ultrasound systems, antiseptic, antibacterial, anti-inflammatory and reparative medicinal products. These techniques and tools can be applied for treatment of diverse pathological conditions and combined with other types of treatment (orthopedic and surgical). The paper presents outcomes of modern research studies investigating etiopathogenetic aspects of periodontal pathology to understand features of complex therapy. It also covers issues of application of nature-based products: phytopreparations, polysaccharide-based products containing hyaluronic acid. As stated various physical factors have a beneficial effect on periodontal tissues depending on the nature of their action. Their differentiated application combined with pharmaceuticals allows purposefully influencing various components of the etiology and pathogenesis to treat gingivitis and periodontitis in young, middle-aged and elderly patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>inflammatory periodontal disease</kwd><kwd>biofilm</kwd><kwd>drug therapy</kwd><kwd>hyaluronic acid</kwd><kwd>physical factors</kwd></kwd-group><kwd-group xml:lang="en"><kwd>inflammatory periodontal disease</kwd><kwd>biofilm</kwd><kwd>drug therapy</kwd><kwd>hyaluronic acid</kwd><kwd>physical factors</kwd></kwd-group></article-meta></front><back><ref-list><title>Список литературы</title><ref id="B1"><mixed-citation>Abdurahmanova S.A., Runova G.S. 2018. Obzor sovremennyh fitopreparatov, primenjaemyh v lechenii vospalitel&amp;#39;nyh zabolevanij parodonta [Review of modern phytopreparations used in the treatment of inflammatory periodontal diseases]. Rossijskaja stomatologija, 11 (4): 37&amp;ndash;41.</mixed-citation></ref><ref id="B2"><mixed-citation>Belenova I.A., Kalinina E.S., Kumirova O.A., Kunin A.A., Olejnik O.I., Popova T.A. 2010. Sovremennyj vzgljad na problemu razrabotki programm profilaktiki zabolevanij tkanej parodonta [A modern view on the problem of developing programs for the prevention of periodontal tissue diseases]. Vestnik novyh medicinskih tehnologij, 17 (2): 163&amp;ndash;165.</mixed-citation></ref><ref id="B3"><mixed-citation>Belenova I.A., Mitronin V.A., Sudareva A.V., Starceva S.V., Vasil&amp;#39;eva M.S., Olejnik E.A. 2022. Sohranit&amp;#39; molodost&amp;#39; parodonta: pravda ili mif? Strategija i takticheskie podhody v periodontologii na osnove profilakticheskoj, prediktivnoj, personificirovannoj mediciny[To preserve the youth of periodontal disease: truth or myth? Strategy and tactical approaches in periodontology based on preventive, predictive, personalized medicine]. Jendodontija today, 20 (1): 0-0. DOI: 10.36377/1683-2981-2022-20-1-0-0.</mixed-citation></ref><ref id="B4"><mixed-citation>Bolatova L.H. 2010. Lechenie vospalitel&amp;#39;nyh zabolevanij parodonta preparatami na osnove gialuronovoj kisloty gruppy &amp;laquo;Gialudent&amp;raquo; [Treatment of inflammatory periodontal diseases with preparations based on hyaluronic acid of the &amp;quot;Hyaludent&amp;quot; group]. Abstract dis. &amp;hellip; cand. med. sciences. Stavropol&amp;#39;, 20 s.</mixed-citation></ref><ref id="B5"><mixed-citation>Bol&amp;#39;shedvorskaja N.E., Kazankova E.M., Belozerceva O.P. 2016. Principy lechenija vospalitel&amp;#39;nogo processa v parodonte [Principles of treatment of the inflammatory process in periodontal disease]. Nauchnyj al&amp;#39;manah, 18 (4&amp;ndash;3): 294&amp;ndash;297.</mixed-citation></ref><ref id="B6"><mixed-citation>Burhonova N.D. 2019. K voprosu zabolevanija parodonta [On the issue of periodontal disease]. Mirovaja nauka, 04: 217&amp;ndash;220.</mixed-citation></ref><ref id="B7"><mixed-citation>Derjabina E.V. 2019. Patofiziologicheskoe obosnovanie kvantovometabolicheskoj terapii i prognozirovanie ee jeffektivnosti pri hronicheskom parodontite [Pathophysiological substantiation of quantum-metabolic therapy and prediction of its effectiveness in chronic periodontitis]. Dis. ... candidate of мedical sciences. Yekaterinburg, 167 s.</mixed-citation></ref><ref id="B8"><mixed-citation>Dmitrieva L.A., Maksimovskij Ju.M. 2021. Terapevticheskaja stomatologija: nacional&amp;#39;noe rukovodstvo [Therapeutic Dentistry: a national guide]. 2-e izd., pererab. i dop. &amp;ndash; Moskva : GЕOTAR-Media, 888 s. URL: https://www.rosmedlib.ru/book/ISBN9785970460979.html (data obrashcheniya: 30.03.2022).</mixed-citation></ref><ref id="B9"><mixed-citation>Dzyuba E.V., Nagaeva M.O., Zhdanova E.V. 2019. Rol&amp;#39; immunologicheskih processov v razvitii vospalitel&amp;#39;nyh zabolevanij parodonta i vozmozhnosti ih korrekcii [The role of immunological processes in the development of inflammatory periodontal diseases and the possibility of their correction]. Problemy stomatologii. 15 (2): 25&amp;ndash;31. DOI: 10.18481/2077-7566-2019-15-2-25-31.</mixed-citation></ref><ref id="B10"><mixed-citation>Dudar&amp;#39; M.V. 2020. Jeksperimental&amp;#39;noe obosnovanie primenenija terpenoidsoderzhashhego rastitel&amp;#39;nogo sredstva v patogeneticheskom lechenii parodontita [Experimental substantiation of the use of a terpenoid-containing herbal remedy in the pathogenetic treatment of periodontitis]. Abstract dis. &amp;hellip; cand. med. sciences. Saratov, 28 s.</mixed-citation></ref><ref id="B11"><mixed-citation>Zakizade A.E., Alieva E.R., Mamedov Z.N. 2018. Racional&amp;#39;nyj podhod k kompleksnoj profilaktike i lecheniju vospalitel&amp;#39;nyh zabolevanij parodonta [A rational approach to the comprehensive prevention and treatment of inflammatory periodontal diseases]. Vestnik problem biologii i mediciny, 1 (3): 370&amp;ndash;373.</mixed-citation></ref><ref id="B12"><mixed-citation>Isanina S.O. 2020. Povyshenie jeffektivnosti lechenija recidivirujushhego aftoznogo stomatita preparatami na osnove gialuronovoj kisloty [Improving the effectiveness of treatment of recurrent aphthous stomatitis with preparations based on hyaluronic acid]. Abstract dis. &amp;hellip; cand. med. sciences. Perm, 20 s.</mixed-citation></ref><ref id="B13"><mixed-citation>Kachesova E.S. 2018. Kliniko-laboratornoe obosnovanie sochetannoj medikamentoznoj terapii parodontita [Clinical and laboratory substantiation of combined drug therapy of periodontitis]. Dis.&amp;nbsp;... cand. med. sciences, 167 s.</mixed-citation></ref><ref id="B14"><mixed-citation>Kosjuga S.Ju., Voinova S.O. 2018. Opyt primenenija gialuronovoj kisloty v lechenii jerozivno-jazvennogo porazhenija slizistoj obolochki rta [Experience in the use of hyaluronic acid in the treatment of erosive and ulcerative lesions of the oral mucosa]. Klinicheskaja stomatologija, 3 (87): 44&amp;ndash;46.</mixed-citation></ref><ref id="B15"><mixed-citation>Kunin A.A., Olejnik O.I., Kubyshkina K.P. 2018. Antimikrobnoe vlijanie medicinskogo ozona na tkani parodonta pri razlichnyh metodah ego primenenija [Antimicrobial effect of medical ozone on periodontal tissues with various methods of its application Periodontology]. Parodontologija, 24&amp;nbsp;(3): 84&amp;ndash;89.</mixed-citation></ref><ref id="B16"><mixed-citation>Lepilin A.V., Ostrovskaja L.Ju., Erokina N.L. 2009. Primenenie stomatologicheskogo kompleksa KAP &amp;ndash; &amp;laquo;PARODONTOLOG&amp;raquo; pri lechenii zabolevanij parodonta [Application of the dental complex CAP&amp;nbsp;&amp;ndash; &amp;laquo;PERIODONTOLOGIST&amp;raquo; in the treatment of periodontal diseases]. Problemy stomatologii, 6: 14&amp;ndash;16.</mixed-citation></ref><ref id="B17"><mixed-citation>Luckaja I.K., Martov V.Ju. 2018. Lekarstvennye sredstva v stomatologii [Medicines in dentistry]. Vtoroe izdanie, pererab. i dop. M., Med. lit., 384 s.</mixed-citation></ref><ref id="B18"><mixed-citation>Mazur I., Bakshkutova N., Ctavckaja D. 2014. Klinicheckaja i mikrobiologicheckaja jeffektivnoct&amp;#39; primenenija mectnyh protivomikrobnyh i anticepticheckih preparatov v lechenii zabolevanij parodonta [Clinical and microbiological efficacy of local antimicrobial and antiseptic drugs in the treatment of periodontal diseases]. DentArt, 2: 24&amp;ndash;32.</mixed-citation></ref><ref id="B19"><mixed-citation>Malazonija T.T. 2018. Kliniko-mikrobiologicheskoe obosnovanie primenenija fotodinamicheskoj terapii i shinirovanija zubov v kompleksnom lechenii zabolevanij parodonta [Clinical and microbiological substantiation of the use of photodynamic therapy and splinting of teeth in the complex treatment of periodontal diseases]. Dis. ... cand. med. sciences. Moscow, 181 s.</mixed-citation></ref><ref id="B20"><mixed-citation>Lamont Richard J., Lantz Marilyn S., Burne Robert A., LeBlanc Donald J. 2010. Mikrobiologija i immunologija dlja stomatologov [Microbiology and immunology for dentists]. M., Prakticheskaja medicina, 504. (Lamont Richard J., Lantz Marilyn S., Burne Robert A., LeBlanc Donald J. 2006. Oral microbiology and immunology. ASM Press, Washington, DC; USA, 504.</mixed-citation></ref><ref id="B21"><mixed-citation>Moiseeva N.S., Kunin A.A. 2018. Klinicheskaja ocenka jeffektivnosti primenenija lechebno-profilakticheskih sredstv v kompleksnoj profilaktike zabolevanij parodonta [Clinical evaluation of the effectiveness of the use of therapeutic and prophylactic agents in the complex prevention of periodontal diseases]. Parodontologija, 23 (1): 19&amp;ndash;21.</mixed-citation></ref><ref id="B22"><mixed-citation>Nikolaev A.I., Cepov L.M. 2021. Prakticheskaya terapevticheskaya stomatologiya: uchebnoe posobie [Practical therapeutic dentistry: a textbook]. 10-e izd., dop. i pererabot. M., MEDpress-inform, 960 s.</mixed-citation></ref><ref id="B23"><mixed-citation>Olejnik O.I., Sorokina M.A., Erina S.V., Kubyshkina K.P. 2013. Ocenka jeffektivnosti primenenija vektor-sistemy v kompleksnom lechenii pacientov s hronicheskim generalizovannym parodontitom srednej stepeni [Evaluation of the effectiveness of the vector system in the complex treatment of patients with chronic generalized periodontitis of moderate degree]. Vestnik novyh medicinskih tehnologij, 20 (2): 138&amp;ndash;143.</mixed-citation></ref><ref id="B24"><mixed-citation>Olejnik O.I., Vusataja E.V., Popova V.S. 2015. Kompleksnyj podhod k lecheniju rannih form vospalitel&amp;#39;nyh zabolevanij parodonta [An integrated approach to the treatment of early forms of inflammatory periodontal diseases]. Molodoj uchenyj, 5 (85): 75&amp;ndash;78.</mixed-citation></ref><ref id="B25"><mixed-citation>Olejnik O.I., Kubyshkina K.P., Olejnik E.A. 2018. Optimizacija lechenija i profilaktiki zabolevanij parodonta putem primenenija lechebnyh adgezivnyh plastin [Optimization of treatment and prevention of periodontal diseases through the use of therapeutic adhesive plates]. Zdorov&amp;#39;e i obrazovanie v XXI veke, 20 (5): 84&amp;ndash;87.</mixed-citation></ref><ref id="B26"><mixed-citation>Orehova L.Ju., Loboda E.S., Jamanidze N.A. 2018. Sovershenstvovanie metodov diagnostiki i lechenija vospalitel&amp;#39;nyh zabolevanij parodonta s ispol&amp;#39;zovaniem razlichnyh form preparatov ozona putem ocenki mikrocirkuljacii tkanej parodonta [Improving the methods of diagnosis and treatment of inflammatory periodontal diseases using various forms of ozone preparations by assessing the microcirculation of periodontal tissues]. Parodontologija, 1 (86): 58&amp;ndash;63.</mixed-citation></ref><ref id="B27"><mixed-citation>Orehova L.Ju., Loboda E.S., Jamanidze N.A., Galeeva A.R. 2018. Primenenie gialuronovoj kisloty v kompleksnom lechenii zabolevanij parodonta [The use of hyaluronic acid in the complex treatment of periodontal diseases]. Parodontologija, 3 (24): 25&amp;ndash;29. DOI 10.25636/PMP.1.2018.3.4.</mixed-citation></ref><ref id="B28"><mixed-citation>Peshkova E.K., Tsimbalistov A.V. 2019. Vliyaniye paradontologicheskoy infektsii na zdorov&amp;#39;ye cheloveka (obzor literatury) [Influence of periodontal infection on human health (review)]. Nauchnyye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya: Meditsina. Farmatsiya, 4: 497&amp;ndash;506.</mixed-citation></ref><ref id="B29"><mixed-citation>Popova V.S., Sushchenko A.V., Vusataya E.V. 2019. Rezul&amp;#39;taty primeneniya gelya s bakteriofagami &amp;laquo;fagodent&amp;raquo; pri profilaktike vospalitel&amp;#39;nyh zabolevanij parodonta u rabotnikov metallurgicheskogo proizvodstva [The results of the use of the gel with bacteriophages &amp;laquo;phagodent&amp;raquo; in the prevention of inflammatory periodontal diseases in workers of metallurgical production]. Vestnik novyh medicinskih tekhnologij. Elektronnoe izdanie. 2: 13&amp;ndash;16. DOI: 10.24411/2075-4094- 2019-16253.</mixed-citation></ref><ref id="B30"><mixed-citation>Prokopenko M.V., Sushhenko A.V. 2021. Kompleksnyj analiz primenenija fitopreparata &amp;laquo;Parodontocid&amp;raquo; v konservativnom lechenii bol&amp;#39;nyh hronicheskim parodontitom legkoj stepeni [Complex analysis of the use of the phytopreparation &amp;laquo;Periodontocide&amp;raquo; in the conservative treatment of patients with mild chronic periodontitis]. Vestnik novyh medicinskih tehnologij, 15 (2): 60&amp;ndash;65.</mixed-citation></ref><ref id="B31"><mixed-citation>Prokopenko M.V. 2021. Primenenie fitopreparatov v lechenii legkoj formy hronicheskogo generalizovannogo parodontita [The use of phytopreparations in the treatment of a mild form of chronic generalized periodontitis]. Abstract dis. &amp;hellip; cand. med. sciences: Voronezh, 24 s.</mixed-citation></ref><ref id="B32"><mixed-citation>Razumova S.N., Moroz A.F. 2018. Mikrobiocenoz polosti rta u pacientov razlichnyh vozrastnyh grupp [Microbiocenosis of the oral cavity in patients of different age groups]. Zhurnal mikrobiologii, jepidemiologii i immunobiologii, 3: 74&amp;ndash;80.</mixed-citation></ref><ref id="B33"><mixed-citation>Risovannaja O., Lalieva Z. 2019. Fotodinamicheskaja terapija v praktike vracha-stomatologa [Photodynamic therapy in the practice of a dentist]. DentArt, 2 (95): 57&amp;ndash;62.</mixed-citation></ref><ref id="B34"><mixed-citation>Sambulov D.V., Haritonov D.Ju., Morozov A.N., Belenova I.A., Podoprigora A.V. 2018. Opredelenie faktorov, vlijajushhih na soderzhanie gialuronana v rotovoj zhidkosti [Determination of factors influencing the content of hyaluronate in the oral fluid]. Medicinskij vestnik Severnogo Kavkaza, 3&amp;nbsp;(2): 389&amp;ndash;391.</mixed-citation></ref><ref id="B35"><mixed-citation>Sinev I.I. 2021. Usovershenstvovanie ortopedicheskogo metoda v kompleksnom lechenii pacientov s lokalizovannym parodontitom srednej stepeni tjazhesti [Improvement of the orthopedic method in the complex treatment of patients with localized periodontitis of moderate severity]. Dis. ... сandidate of мedical sciences. Samara, 146 s.</mixed-citation></ref><ref id="B36"><mixed-citation>Soldatova E.S. 2018. Razrabotka shemy kompleksnogo lechenija vospalitel&amp;#39;nyh zabolevanij parodonta [Development of a scheme of complex treatment of inflammatory periodontal diseases]. Dis. ... сand. мed. sciences. Ufa, 132 s.</mixed-citation></ref><ref id="B37"><mixed-citation>Tarasenko S.V., Kulaga O.I. 2016. Preparaty na osnove gialuronovoj kisloty dlja lechenija pacientov s hronicheskim generalizovannym parodontitom (literaturnyj obzor) [Preparations based on hyaluronic acid for the treatment of patients with chronic generalized periodontitis (literature review)]. Rossijskij stomatologicheskij zhurnal, 20 (6): 340&amp;ndash;343.</mixed-citation></ref><ref id="B38"><mixed-citation>Ulitovskij S.B., Shevcov A.V. 2020. Izuchenie rasprostranennosti zabolevanij parodonta u ortodonticheskih pacientov [To study the prevalence of periodontal diseases in orthodontic patients]. Parodontologija, 25 (1): 37&amp;ndash;41. https://doi.org/10.33925/1683-3759-2020-25-1-37-41.</mixed-citation></ref><ref id="B39"><mixed-citation>Uspenskaja O.A., Kalinkin K.I. 2020. Uroven&amp;#39; stomatologicheskogo prosveshhenija u studentov g. N.&amp;nbsp;Novgoroda [The level of dental education among students of the city of Nizhny Novgorod]. Problemy stomatologii, 16 (1): 58&amp;ndash;63.</mixed-citation></ref><ref id="B40"><mixed-citation>Uspenskaja O.A., Kruglova N.V., Kochubejnik A.V. 2020. Vybor sredstv gigieny polosti rta pri nalichii u pacienta otjagoshhennogo allergologicheskogo anamneza (kratkij obzor) [The choice of oral hygiene products in the presence of a patient with a burdened allergic history (a brief overview)]. Cathedra-Kafedra. Stomatologicheskoe obrazovanie, 72&amp;ndash;73: 80&amp;ndash;83.</mixed-citation></ref><ref id="B41"><mixed-citation>Uspenskaja O.A., Spiridonova S.A., Ruzina K.A. 2021. Izuchenie psihojemocional&amp;#39;nogo statusa i gigienicheskogo sostojanija polosti rta studentov, nahodjashhihsja na distancionnom obuchenii na fone COVID-19 [The study of the psychoemotional status and hygienic condition of the oral cavity of students who are on distance learning against the background of COVID-19].Dental Forum, 4&amp;nbsp;(79): 59&amp;ndash;60.</mixed-citation></ref><ref id="B42"><mixed-citation>Uspenskaja O.A., Spiridonova S.A., Suhova A.V. 2020. Izuchenie vlijanija sostojanija polosti rta na psihojemocional&amp;#39;nyj status obuchajushhihsja stomatologicheskogo fakul&amp;#39;teta &amp;laquo;Privolzhskogo issledovatel&amp;#39;skogo medicinskogo universiteta&amp;raquo; Ministerstva zdravoohranenija Rossijskoj Federacii [The study of the influence of the oral cavity on the psycho-emotional status of students of the Dental Faculty of the Volga Research Medical University of the Ministry of Health of the Russian Federation]. Jendodontija Today, 18 (1): 77&amp;ndash;81.</mixed-citation></ref><ref id="B43"><mixed-citation>Fizioterapija stomatologicheskih zabolevanij: ucheb. posobie. pod red. Kunina A.A. 2012. Voronezh, Novyj vzgljad, 260 s.</mixed-citation></ref><ref id="B44"><mixed-citation>Hachaturov S.S. 2021. Jeffektivnost&amp;#39; medikamentoznoj i lazernoj terapii pri lechenii vospalitel&amp;#39;nyh zabolevanij parodonta [The effectiveness of drug and laser therapy in the treatment of inflammatory periodontal diseases]. Abstract dis. &amp;hellip; cand. med. sciences. Voronezh, 23.</mixed-citation></ref><ref id="B45"><mixed-citation>Carev V.Ja., Ushakov R.V. 2019. Antimikrobnaja terapija v stomatologii. Principy i algoritmy [Antimicrobial therapy in dentistry. Principles and algorithms]. Rukovodstvo, 2-e izdanie. Moskva, 240 s.</mixed-citation></ref><ref id="B46"><mixed-citation>Cepov L.M., Nikolaev A.I. 2020. K voprosu ob jetiologii i patogeneze vospalitel&amp;#39;nyh zabolevanij parodonta [On the etiology and pathogenesis of inflammatory periodontal diseases]. Parodontologija, 2: 9&amp;ndash;13.</mixed-citation></ref><ref id="B47"><mixed-citation>Janushevich O.O., Dmitrieva L.A. 2018. Parodontologija: nacional&amp;#39;noe rukovodstvo [Periodontology: a national guide]. Moscow: GЕOTAR-Media, 752. URL: https://www.rosmedlib.ru/book/ISBN9785970443651.html (data obrashhenija: 30.03.2022).</mixed-citation></ref><ref id="B48"><mixed-citation>Janushevich O.O., Dmitrieva L.A., Revazova Z.Je. 2016. Parodontit. XXI vek [Periodontitis. XXI centur]. Moscow: GЕOTAR-Media, 480. URL: https://www.rosmedlib.ru/book/ISBN9785970439777 html (data obrashhenija: 30.03.2022).</mixed-citation></ref><ref id="B49"><mixed-citation>Chapple, IL.C., Mealey B.L. 2018. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and PeriоImplant Diseases and Conditions. J. Clin Periodontol, 45&amp;nbsp;(20): 68&amp;ndash;77.</mixed-citation></ref><ref id="B50"><mixed-citation>Jin J., Sklar G.E., Oh M.S. 2018. Factors affecting therapeutic compliance: A review from the patient&amp;rsquo;s perspective. Therapeutics and Clinical Risk Management, 4 (1): 269&amp;ndash;286.</mixed-citation></ref><ref id="B51"><mixed-citation>Kubyshkina К.P., Podoprigora A.V., Oleynik O.I., Kharitonov U.M., Belenova I.A. 2018. Statistical evaluation of antimicrobial influence of medical ozone as a part of inflammatory prevention of periodontal diseases. Research Journal Of Pharmaceutical, Biological And Chemical Sciences, 9&amp;nbsp;(6): 690&amp;ndash;696.</mixed-citation></ref><ref id="B52"><mixed-citation>Kunin A., Polivka J.Jr., Moiseeva N., Golubnitschaja O. 2018. &amp;laquo;Dry mouth&amp;raquo; and &amp;laquo;Flammer&amp;raquo; syndromes-neglected risks in adolescents and new concepts by predictive, preventive and personalised approach. EPMA J., 9 (3): 307&amp;ndash;317. doi: 10.1007/s13167-018-0145-7.</mixed-citation></ref><ref id="B53"><mixed-citation>Lang N.P., Bartold P.M. 2018. Periodontal health. J. Clin. Periodontol. 45 (20): 230&amp;ndash;236.</mixed-citation></ref><ref id="B54"><mixed-citation>Tachalov V.V., Orekhova L.Y., Isaeva E.R., Kudryavtseva T.V., Loboda E.S., Sitkina E.V. 2018. Characteristics of dental patients determining their compliance level in dentistry: relevance for predictive, preventive, and personalized medicine. EPMA J., 9 (4): 379&amp;ndash;385. doi: 10.1007/s13167-018-0152-8.5.</mixed-citation></ref><ref id="B55"><mixed-citation>Tachalov V.V., Orekhova L.Y., Kudryavtseva T.V., Loboda E.S., Pachkoriia M.G., Berezkina I.V., Golubnitschaja O. 2021. Making a complex dental care tailored to the person: population health in focus of predictive, preventive and personalised (3P) medical approach. EPMA J., 12 (2): 1&amp;ndash;12. doi: 10.1007/s13167-021-00240-7.</mixed-citation></ref><ref id="B56"><mixed-citation>Twetman S., Derawi B., Keller M., Ekstrand K., Yucel-Lindberg T., Stecks&amp;eacute;n-Blicks C. 2019. Short term effect of chewing gum containing probiotics lactobacillus reutri on levels of inflammatory mediators in GCF. Acta Odontologica Scandinavica, 67: 19&amp;ndash;24.</mixed-citation></ref></ref-list></back></article>