Список литературы

2687-0940

Challenges in modern medicine

2687-0940

10.52575/2687-0940-2022-45-1-28-38

103

INTERNAL DISEASES

<strong>Influence of interleukin-21 on the state of intracellular signaling mechanisms in leukocytes in patients with pneumonia</strong>

Bondar

Stanislav S.

Bondar

Stanislav S.

Terekhov

Igor V.

Terekhov

Igor V.

trft@mail.ru

Nikiforov

Viktor S.

Nikiforov

Viktor S.

Parfenyuk

Vladimir K.

Parfenyuk

Vladimir K.

Bondar

Nelli V.

Bondar

Nelli V.

2022

45100

The results of a study of possible mechanisms of the influence of interleukin-21 on the functional state of blood cells and their production of cytokines in people who have had pneumonia are presented. Purpose: to study the effect of interleukin-21 on the state of signaling mechanisms, in particular, mitogen-activated / stress-activated signaling pathways, the level of heat shock proteins and histones in peripheral blood mononuclear leukocytes in community-acquired pneumonia convalescents, as well as the production of interleukins and growth factors. 40 male patients from 18 to 43 years old with community-acquired pneumonia on the 13–15th day of the disease were examined. Results. In persons who have had pneumonia, the level of interleukin-21 is associated with the state of mitogen-activated / stress-activated signaling pathways, as well as the signaling pathway associated with Janus kinases and signal transducers and transcription activators, determining the cytokine profile and features of the postclinical phase of the disease in such patients.

interleukin-21pneumoniacytokinesgrowth factorsimmunorehabilitationintracellular signaling pathwaystranscription factorsinflammation

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