MYOCARDIAL INFARCTION AND COMBORBIDITY IN PATIENTS OF YOUNG AND MIDDLE AGES: EXPERIENCE OF THE REGIONAL VASCULAR CENTER
Nowadays in real clinical practice there are a lot of patients with comorbidity. Based on these, the problem of comorbidity in patients with cardiovascular diseases attracts the attention of medical specialists. However, in the domestic medical journals there is no information about the presence and prognostic significance of concomitant diseases in patients with myocardial infarction (MI) of working age. The aim of our study was to estimate the frequency of occurrence, gender and age characteristics of comorbidity in young and middle aged patients with MI and to present its prognostic significance. The study population consisted of 424 patients (median age of 50 (43.5; 55.0) years), treated in the regional vascular center of Perm city during the period of 2018–2019. In addition to the standard clinical, instrumental and laboratory examination, the Charlson Comorbidity Index (CI) was calculated for every patient. In general, the rate of comorbidity in patients with MI was average (CI = 2.71 ± 0.08 points), while the number of diseases was dependent on the patient‘s age and gender. The statistically significant increase in CI was observed in patients older than 40 years (OR = 12.35; 95 % CI: 5.76–26.46, p = 0.0001). The risk of recurring coronary events in patients with MI increased in those who had CI > 2 (OR = 2.59; 95 % CI: 1.11–5.89, p = 0.027). If the CI was > 4, the level of post-hospital mortality had been increased (OR = 3.82; 95 % CI: 1.34–10.91, p = 0.012).