Mechanism of exposure to molecular hydrogen in complex treatment of soft tissue wounds and general surgical infection
Molecular hydrogen (MH) has been known for a long time as an inert gas, but its beneficial properties became known only in 2007, when information about its antioxidant capabilities was obtained. The effects of MH make it possible to use it in the complex treatment of soft tissue wounds. This review discusses the main biological actions, as well as the mechanisms of action of MH in violation of the integrity of tissue structures and septic damage to organs from the main abilities of hydrogen: anti-apoptotic, anti-inflammatory, antioxidant, and autophagic. The methods of transportation, dosage of H2, as well as their advantages and disadvantages in practical medicine are described in detail. The prospects for the development of its implementation in the most diverse areas of treatment and the main problems, which still have no answer, are considered.
Andreev A.A., Laptiyova A.Yu., Glukhov A.A., Konyashin D.A., Konovalov P.A., Zolotyhin V.O.2021. Mechanism of exposure to molecular hydrogen in complex treatment of soft tissue wounds and general surgical infection. Challenges in Modern Medicine. 44 (4): 460–470 (in Russian). DOI: 10.52575/2687-0940-2021-44-4-460-470.
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